Drs. Clendenon and Sarmah contributed equally to this work.
Zebrafish cadherin-11 participates in retinal differentiation and retinotectal axon projection during visual system development
Article first published online: 13 JAN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Volume 241, Issue 3, pages 442–454, March 2012
How to Cite
Clendenon, S. G., Sarmah, S., Shah, B., Liu, Q. and Marrs, J. A. (2012), Zebrafish cadherin-11 participates in retinal differentiation and retinotectal axon projection during visual system development. Dev. Dyn., 241: 442–454. doi: 10.1002/dvdy.23729
- Issue published online: 14 FEB 2012
- Article first published online: 13 JAN 2012
- Accepted manuscript online: 3 JAN 2012 03:22PM EST
- Manuscript Accepted: 19 DEC 2011
- NIH. Grant Numbers: RO1 DC006436, R15 EY13879
- visual system development;
- antisense oligonucleotide
Background: Cadherins orchestrate tissue morphogenesis by controlling cell adhesion, migration and differentiation. Various cadherin family members are expressed in the retina and other neural tissues during embryogenesis, regulating development of these tissues. Cadherin-11 (Cdh11) is expressed in mesenchymal, bone, epithelial, neural and other tissues, and this cadherin was shown to control cell migration and differentiation in neural crest, tumor and bone cells. Our previous studies characterized Cdh11 expression and function in zebrafish. Results: Here, we report effects of Cdh11 loss-of-function on visual system development using morpholino oligonucleotide knockdown methods. Cdh11 is expressed in the retina and lens during retinal differentiation. Cdh11 loss-of-function produced defects in retinal differentiation and lens development. Cdh11 loss-of-function also reduced retinotectal axon projection and organization, consistent with known Cdh11 function in cell migration. Conclusion: Cdh11 expression in the developing visual system and Cdh11 loss-of-function phenotype illustrates the critical role for differential cadherin activity in visual system differentiation and organization. Developmental Dynamics 241:442–454, 2012. © 2012 Wiley Periodicals, Inc.