Patterns & Phenotypes
ILF-3 is a regulator of the neural plate border marker Zic1 in chick embryos
Article first published online: 15 JUN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Volume 241, Issue 8, pages 1325–1332, August 2012
How to Cite
Fishwick, K. J., Kim, E. and Bronner, M. E. (2012), ILF-3 is a regulator of the neural plate border marker Zic1 in chick embryos. Dev. Dyn., 241: 1325–1332. doi: 10.1002/dvdy.23809
- Issue published online: 17 JUL 2012
- Article first published online: 15 JUN 2012
- Accepted manuscript online: 25 MAY 2012 10:31AM EST
- Manuscript Accepted: 20 MAY 2012
- NIH. Grant Number: HG004071
- neural crest;
- neural plate border
Background: The neural crest is a multipotent cell type unique to the vertebrate lineage and capable of differentiating into a large number of varied cell types, including ganglia of the peripheral nervous system, cartilage, and glia. An early step in neural crest specification occurs at the neural plate border, a region defined by the overlap of transcription factors of the Zic, Msx, and Pax families. Results: Here we identify a novel chick gene with close homology to double-stranded RNA-binding protein Interleukin enhancer binding factor 3 (ILF-3) in other species. Our results show that chick Ilf-3 is required for proper expression of the transcription factor, Zic-1, at the neural plate border. Conclusion: We have identified a novel chick gene and show it has a role in the correct specification of Zic-1 at the neural plate border. Developmental Dynamics 241:1325–1332, 2012. © 2012 Wiley Periodicals, Inc.