Patterns & Phenotypes

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Tissue-specific responses to aberrant FGF signaling in complex head phenotypes†

  1. Neus Martínez-Abadías1,‡,
  2. Susan M. Motch1,§,
  3. Talia L. Pankratz1,
  4. Yingli Wang2,
  5. Kristina Aldridge3,§,
  6. Ethylin Wang Jabs2,
  7. Joan T. Richtsmeier1,§,*

Article first published online: 5 DEC 2012

DOI: 10.1002/dvdy.23903

Issue

Developmental Dynamics

Developmental Dynamics

Volume 242, Issue 1, pages 80–94, January 2013

Additional Information

How to Cite

Martínez-Abadías, N., Motch, S. M., Pankratz, T. L., Wang, Y., Aldridge, K., Jabs, E. W. and Richtsmeier, J. T. (2013), Tissue-specific responses to aberrant FGF signaling in complex head phenotypes. Dev. Dyn., 242: 80–94. doi: 10.1002/dvdy.23903

Author Information

  1. 1

    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania

  2. 2

    Department of Genetics and Genomic Sciences, Mount Sinai SOM, New York, New York

  3. 3

    Department of Pathology and Anatomical Sciences, University of Missouri SOM, Columbia, Missouri

  1. ‡

    CRG, Center for Genomic Regulation, Barcelona, Spain

  1. §

    Neus Martínez-Abadías, Susan M. Motch, and Joan T. Richtsmeier contributed equally to the manuscript.

*Department of Anthropology, Pennsylvania State University, 409 Carpenter Building, University Park, PA 16803

  1. †

    All authors declare that there are no conflicts of interest.

  2. §

    Neus Martínez-Abadías, Susan M. Motch, and Joan T. Richtsmeier contributed equally to the manuscript.

Publication History

  1. Issue published online: 11 DEC 2012
  2. Article first published online: 5 DEC 2012
  3. Accepted manuscript online: 21 NOV 2012 12:03PM EST
  4. Manuscript Accepted: 2 NOV 2012
  5. Manuscript Revised: 30 OCT 2012
  6. Manuscript Received: 17 SEP 2012

Funded by

  • NIH. Grant Numbers: R01DE018500, R01DE022988
  • NIH and the American Recovery and Reinvestment Act. Grant Number: 3R01DE018500-02S1
  • Comissionat per a Universitaats I Recerca (CUR), Generalitat de Catalunya, Spain. Grant Number: 2008 BP A 00170

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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
DVDY_23903_sm_SuppVideo1.avi6205KSupporting Information Video 1. 3D reconstruction of isosurface of P0 mouse skull showing linear distances (measured between 3D coordinate locations of landmarks) that are significantly different in Fgfr2cC342Y/+ Crouzon syndrome mutant mice relative to unaffected littermates when landmarks from global skull are analyzed by EDMA (Lele and Richtsmeier, 2001). Blue lines are significantly larger in mutant mice relative to unaffected littermates. Fuchsia lines are significantly smaller in mutant mice. Significant differences are shown on facial skeleton and palate in video S1 and on cranial vault and cranial base in video S2.
DVDY_23903_sm_SuppVideo2.avi6810KSupporting Information Video 2. 3D reconstruction of isosurface of P0 mouse skull showing linear distances (measured between 3D coordinate locations of landmarks) that are significantly different in Fgfr2cC342Y/+ Crouzon syndrome mutant mice relative to unaffected littermates when landmarks from global skull are analyzed by EDMA (Lele and Richtsmeier, 2001). Blue lines are significantly larger in mutant mice relative to unaffected littermates. Fuchsia lines are significantly smaller in mutant mice. Significant differences are shown on facial skeleton and palate in video S1 and on cranial vault and cranial base in video S2.

Please note: Wiley-Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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