Andrew Cutting and Justin Chue contributed equally to this work.
Special Issue Reviews-A Peer Review Forum
Just how conserved is vertebrate sex determination?
Article first published online: 6 MAR 2013
Copyright © 2013 Wiley Periodicals, Inc.
Special Issue: Sex Determination
Volume 242, Issue 4, pages 380–387, April 2013
How to Cite
Cutting, A., Chue, J. and Smith, C. A. (2013), Just how conserved is vertebrate sex determination?. Dev. Dyn., 242: 380–387. doi: 10.1002/dvdy.23944
- Issue published online: 20 MAR 2013
- Article first published online: 6 MAR 2013
- Accepted manuscript online: 6 FEB 2013 08:55AM EST
- Manuscript Accepted: 21 DEC 2012
- Manuscript Revised: 20 DEC 2012
- Manuscript Received: 13 DEC 2012
- sex determination;
- gonadal differentiation
Background: Sex determination in vertebrate embryos has long been equated with gonadal differentiation into testes or ovaries. This view has been challenged over the years by reports of somatic sexual dimorphisms pre-dating gonadal sex differentiation. The recent finding that sex determination in birds is likely to be partly cell autonomous has again called for a broader definition of sex determination. Inherent sexual differentiation in each and every cell may apply widely among vertebrates, and may involve more than one “master sex gene” on a sex chromosome. At the gonadal level, key genes required for proper sexual differentiation are conserved among vertebrates, but their relative positions in the ovarian and testicular cascades differ. Results: We illustrate these differences by comparing key sex genes in fishes versus birds and mammals, with emphasis on DM domain genes and the SOX9-AMH pathway in the testis and the FOXL2-Aromatase pathway in the ovary. Such comparisons facilitate the identification of ancient versus derived genes involved in gonadal sex determination. Conclusions: The data indicate that vertebrate sex-determining cascades are not as conserved as once thought. Developmental Dynamics 242:380–387, 2013. © 2013 Wiley Periodicals, Inc.