Drs. Hui and Managhan contributed equally to this work.
Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord
Article first published online: 3 JUN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 242, Issue 7, pages 847–860, July 2013
How to Cite
Hui, S. P., Monaghan, J. R., Voss, S. R. and Ghosh, S. (2013), Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord. Dev. Dyn., 242: 847–860. doi: 10.1002/dvdy.23976
- Issue published online: 17 JUN 2013
- Article first published online: 3 JUN 2013
- Accepted manuscript online: 17 APR 2013 04:18AM EST
- Manuscript Accepted: 28 MAR 2013
- Manuscript Revised: 26 MAR 2013
- Manuscript Received: 16 JAN 2013
- Department of Science and Technology, Government of India. Grant Number: SR/SO/AS-26/2004
- Department of Biotechnology, Government of India. Grant Number: DBT/BT/PR13953/AAQ/03/523/2010
- Kentucky Spinal Cord and Brain Injury Research Trust
- National Science Foundation
- spinal cord injury (SCI);
- Nogo receptor (NgR);
- myelin associated glycoprotein (MAG)
Background: The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration. Results: Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells. Conclusions: These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls. Developmental Dynamics 242:847–860, 2013. © 2013 Wiley Periodicals, Inc.