Canonical Wnt signaling regulates Nkx3.1 expression and luminal epithelial differentiation during prostate organogenesis

Authors

  • Marianna Kruithof-de Julio,

    1. Departments of Medicine and Genetics and Development, Columbia University Medical Center, New York, New York
    2. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York
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  • Maho Shibata,

    1. Departments of Medicine and Genetics and Development, Columbia University Medical Center, New York, New York
    2. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York
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  • Nishita Desai,

    1. Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway, New Jersey
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  • Melissa Reynon,

    1. Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway, New Jersey
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  • M. Vivienne Halili,

    1. Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway, New Jersey
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  • Ya-Ping Hu,

    1. Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway, New Jersey
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  • Sandy M. Price,

    1. Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway, New Jersey
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  • Cory Abate-Shen,

    1. Departments of Medicine and Genetics and Development, Columbia University Medical Center, New York, New York
    2. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York
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  • Michael M. Shen

    Corresponding author
    1. Departments of Medicine and Genetics and Development, Columbia University Medical Center, New York, New York
    2. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York
    • Correspondence to: Michael M. Shen, Departments of Medicine and Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032 E-mail: mshen@columbia.edu

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Abstract

COVER PHOTOGRAPH: Inhibition of canonical Wnt signaling affects prostate bud outgrowth and luminal epithelial differentiation in explant culture. Immunostaining for FoxA1 (red) and cytokeratin 5 (green) in a section from a 15.5 dpc urogenital sinus explant cultured for 7 days in Dkk1-containing media. From Canonical Wnt Signaling Regulates Nkx3.1 Expression and Luminal Epithelial Differentiation During Prostate Organogenesis, Marianna Kruithof-de Julio, Maho Shibata, Nishita Desai, Melissa Reynon, M. Vivienne Halili, Ya-Ping Hu, Sandy M. Price, Cory Abate-Shen, and Michael M. Shen, Developmental Dynamics 242:1160–1171.

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