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Developmental Dynamics

Cover image for Vol. 241 Issue 1

Special Issue: Special Issue on Drosophila

January 2012

Volume 241, Issue 1

Pages spcone–spcone, 1–228

Issue edited by: Amit Singh, Kenneth D. Irvine

  1. Cover

    1. Top of page
    2. Cover
    3. Highlights
    4. ArtPix
    5. Special Issue Perspectives
    6. Special Issue Reviews–A Peer Reviewed Forum
    7. Special Issue Research Articles
    8. Special Issue Techniques
    9. Special Issue Disease Connections
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  2. Highlights

    1. Top of page
    2. Cover
    3. Highlights
    4. ArtPix
    5. Special Issue Perspectives
    6. Special Issue Reviews–A Peer Reviewed Forum
    7. Special Issue Research Articles
    8. Special Issue Techniques
    9. Special Issue Disease Connections
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      Highlights in DD (page vi)

      Julie C. Kiefer

      Article first published online: 15 DEC 2011 | DOI: 10.1002/dvdy.22777

  3. ArtPix

    1. Top of page
    2. Cover
    3. Highlights
    4. ArtPix
    5. Special Issue Perspectives
    6. Special Issue Reviews–A Peer Reviewed Forum
    7. Special Issue Research Articles
    8. Special Issue Techniques
    9. Special Issue Disease Connections
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      DD ArtPix (page vii)

      Article first published online: 15 DEC 2011 | DOI: 10.1002/dvdy.23709

  4. Special Issue Perspectives

    1. Top of page
    2. Cover
    3. Highlights
    4. ArtPix
    5. Special Issue Perspectives
    6. Special Issue Reviews–A Peer Reviewed Forum
    7. Special Issue Research Articles
    8. Special Issue Techniques
    9. Special Issue Disease Connections
    1. You have free access to this content
  5. Special Issue Reviews–A Peer Reviewed Forum

    1. Top of page
    2. Cover
    3. Highlights
    4. ArtPix
    5. Special Issue Perspectives
    6. Special Issue Reviews–A Peer Reviewed Forum
    7. Special Issue Research Articles
    8. Special Issue Techniques
    9. Special Issue Disease Connections
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      Hippo signaling in Drosophila: Recent advances and insights (pages 3–15)

      Binnaz Kucuk Staley and Kenneth D. Irvine

      Article first published online: 25 AUG 2011 | DOI: 10.1002/dvdy.22723

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      A glimpse into dorso-ventral patterning of the Drosophila eye (pages 69–84)

      Amit Singh, Meghana Tare, Oorvashi Roy Puli and Madhuri Kango-Singh

      Article first published online: 27 OCT 2011 | DOI: 10.1002/dvdy.22764

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      Drosophila cancer models (pages 107–118)

      Vivek A. Rudrapatna, Ross L. Cagan and Tirtha K. Das

      Article first published online: 28 OCT 2011 | DOI: 10.1002/dvdy.22771

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      Drosophila as a model for epithelial tube formation (pages 119–135)

      Rika Maruyama and Deborah J. Andrew

      Article first published online: 14 NOV 2011 | DOI: 10.1002/dvdy.22775

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  6. Special Issue Research Articles

    1. Top of page
    2. Cover
    3. Highlights
    4. ArtPix
    5. Special Issue Perspectives
    6. Special Issue Reviews–A Peer Reviewed Forum
    7. Special Issue Research Articles
    8. Special Issue Techniques
    9. Special Issue Disease Connections
    1. You have free access to this content
      Comparison of embryonic expression within multigene families using the flyexpress discovery platform reveals more spatial than temporal divergence (pages 150–160)

      Charlotte E. Konikoff, Timothy L. Karr, Michael McCutchan, Stuart J. Newfeld and Sudhir Kumar

      Article first published online: 29 SEP 2011 | DOI: 10.1002/dvdy.22749

      Key findings:

      • FlyExpress resource facilitates analysis of expression pattern images from Drosophila embryos.

      • Image-based pattern searching yields fewer but more precise results than text-based searching.

      • Gene family expression more frequently displays spatial divergence than temporal divergence.

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      The MicroRNA miR-8 is a positive regulator of pigmentation and eclosion in Drosophila (pages 161–168)

      Jennifer A. Kennell, Ken M. Cadigan, Iryna Shakhmantsir and Evan J. Waldron

      Article first published online: 15 DEC 2011 | DOI: 10.1002/dvdy.23705

      Key findings:

      • miR-8 is required for proper spatial patterning of pigment on adult female abdomens.

      • The pigmentation patterning defect in miR-8 mutants is independent of the small body size defect.

      • Loss of miR-8 in the developing cuticle results in cell-autonomous loss of pigmentation.

      • MiR-8 is expressed in the epidermis underlying the dorsal abdominal cuticle.

      • Loss of miR-8 sensitizes flies to effects of higher growth temperatures on eclosion success and pigmentation patterning.

  7. Special Issue Techniques

    1. Top of page
    2. Cover
    3. Highlights
    4. ArtPix
    5. Special Issue Perspectives
    6. Special Issue Reviews–A Peer Reviewed Forum
    7. Special Issue Research Articles
    8. Special Issue Techniques
    9. Special Issue Disease Connections
    1. You have full text access to this OnlineOpen article
      Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers (pages 169–189)

      Thomas Brody, Amarendra S. Yavatkar, Alexander Kuzin, Mukta Kundu, Leonard J. Tyson, Jermaine Ross, Tzu-Yang Lin, Chi-Hon Lee, Takeshi Awasaki, Tzumin Lee and Ward F. Odenwald

      Article first published online: 30 AUG 2011 | DOI: 10.1002/dvdy.22728

      Key findings:

      • A genome-wide catalog of Drosophila conserved DNA sequence clusters.

      • cis-Decoder discovers functionally related enhancers.

      • Functionally related enhancers share balanced sequence element copy numbers.

      • Many enhancers function during multiple phases of development.

    2. You have full text access to this OnlineOpen article
      Transactivation in Drosophila of human enhancers by human transcription factors involved in congenital heart diseases (pages 190–199)

      Vincenzo Amodio, Maria Florencia Tevy, Concetta Traina, Tushar Kanti Ghosh and Maria Capovilla

      Article first published online: 11 OCT 2011 | DOI: 10.1002/dvdy.22763

      Key findings:

      • The mammalian transcription factors GATA4, Nkx2.5 and TBX5 are able to transactivate the Nppa and Myh6 human enhancers in Drosophila embryos.

      • The endogenous Drosophila homologs of GATA4, Nkx2.5 and TBX5 are not transactivated by GATA4, Nkx2.5 or TBX5, ruling out a possible endogenous regulatory circuit.

      • Overexpression in the mesoderm of GATA4, Nkx2.5 or TBX5 is lethal and overexpression in eyes and wings causes reduced organs.

  8. Special Issue Disease Connections

    1. Top of page
    2. Cover
    3. Highlights
    4. ArtPix
    5. Special Issue Perspectives
    6. Special Issue Reviews–A Peer Reviewed Forum
    7. Special Issue Research Articles
    8. Special Issue Techniques
    9. Special Issue Disease Connections
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      Hyperactive BMP signaling induced by ALK2R206H requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva (pages 200–214)

      Viet Q. Le and Kristi A. Wharton

      Article first published online: 15 DEC 2011 | DOI: 10.1002/dvdy.22779

      Key findings:

      • FOP mutant ALK2R206H receptor exhibits ligand-independent signaling in Drosophila.

      • Hyperactive ALK2R206H signaling requires BMP type II receptor function.

      • Wild-type ALK2 transduces BMP7-induced signaling but inhibits signaling by Gbb, Dpp, and hBMP4.

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      OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye (pages 215–228)

      David Terrell, Baotong Xie, Michael Workman, Simpla Mahato, Andrew Zelhof, Brian Gebelein and Tiffany Cook

      Article first published online: 23 NOV 2011 | DOI: 10.1002/dvdy.22782

      Key findings:

      • Human OTX factors—OTX1, OTX2 and CRX—perform overlapping, yet distinct subsets of Otd-dependent functions during Drosophila eye development, providing a system to study subfunctionalization of a family of related transcription factors.

      • Human OTX factors rescue the morphogenesis of rhabdomeric photoreceptors, suggesting that ciliary and rhabdomeric photoreceptors arose from a common ancestor requiring an Otd-related factor for its development.

      • Different CRX alleles associated with similar retinal degenerations can be functionally distinguished using the fly eye as a model system.

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