Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm (pages 1545–1561)
Cynthia L. Hsu, Claire P. Muerdter, Abhay D. Knickerbocker, Ryan M. Walsh, Martha A. Zepeda-Rivera, Kevin H. Depner, Maya Sangesland, Trinidad B. Cisneros, Ju Youn Kim, Patricia Sanchez-Vazquez, Lidia Cherezova, Rainy D. Regan, Nadia M. Bahrami, Elizabeth A. Gray, Andrew Y. Chan, Terry Chen, Milly Y. Rao and Merrill B. Hille
Version of Record online: 4 SEP 2012 | DOI: 10.1002/dvdy.23847
p120 catetin is required for extension of the dorsal axis and normal migration of the presomitic mesoderm.
Cdc42 and Rac1 GTPases are downstream of p120 catenin δ1 signaling and require exchange of GTP for GDP.
Local stimulation of the exchange of GTP for GDP in Cdc42 and Rac GTPases mediates directional migration of the presomitic mesoderm.
A balance of the amount of p120 catenin δ1 and localized activation or turnover of Cdc42, Rac1, and Rho GTPase are required for normal zebrafish cell migration.