Ephrin-B stimulation of calvarial bone formation (pages 1901–1910)
M. Douglas Benson, Lynne A. Opperman, Jan Westerlund, Claudia R. Fernandez, Symone San Miguel, Mark Henkemeyer and George Chenaux
Article first published online: 5 NOV 2012 | DOI: 10.1002/dvdy.23874
Ephrin-B2 is highly expressed at sites of active osteogenesis in developing mouse calvaria.
Ephrin-B2 dramatically increases bone growth in embryonic calvaria and osteoblast differentiation in MC3T3-E1 cells independent of type 1 collagen matrix secretion.
EphB1 and EphB2 are expressed at osteogenic sites, consistent with roles as candidate ephrin-B receptors. EphB4, previously thought to be the major ephrin-B2 receptor in osteoblasts, is virtually absent in developing and adult skulls.