3-dimensional morphometric analysis of murine bladder development and dysmorphogenesis (pages 522–533)
Ashley Carpenter, Andrew Paulus, Melissa Robinson, Carlton M. Bates, Michael L. Robinson, David Hains, David Kline and Kirk M. McHugh
Article first published online: 31 JAN 2012 | DOI: 10.1002/dvdy.23744
Detrusor smooth muscle differentiation initiated in the bladder dome and progressed caudally with the leading edge extending down the right posterior surface of the bladder
Gender-specific differences in detrusor smooth muscle development were observed during early embryonic development
Bladder trigone morphology transitioned from an isosceles to equilateral triangle during development due to the preferential lengthening of the urethra to ureter distance.
The primary defect observed in mgb–/– bladders was a significant reduction in detrusor smooth muscle differentiation throughout development.
Deviations from normal trigone morphology correlated best with VUR development in Fgfr2Mes–/– mice, while alterations in intravesicular tunnel length did not.