The transcription factor sry-related HMG box-4 (SOX4) is required for normal renal development in vivo (pages 790–799)
Jez Huang, Michel Arsenault, Martin Kann, Carlos Lopez-Mendez, Monique Saleh, Dorota Wadowska, Mary Taglienti, Jacqueline Ho, Yuan Miao, David Sims, Jonathan Spears, Alfonso Lopez, Glenda Wright and Sunny Hartwig
Version of Record online: 29 APR 2013 | DOI: 10.1002/dvdy.23971
- SoxC genes exhibit overlapping but distinct patterns of expression in the nephrogenic lineages during renal development.
- Conditional ablation of Sox4 in the nephrogenic lineage results in reduced nephron number.
- Postnatal Sox4nephron- mice develop severe early-onset kidney injury leading to renal failure in vivo.