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Developmental Dynamics

Cover image for Vol. 242 Issue 7

July 2013

Volume 242, Issue 7

Pages C1–C1, 801–908

  1. Cover Image

    1. Top of page
    2. Cover Image
    3. Art Pix
    4. Research Articles
    5. Patterns & Phenotypes
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      Drosophila semaphorin2b is required for the axon guidance of a subset of embryonic neurons (page C1)

      Mark M. Emerson, Jennifer B. Long and David Van Vactor

      Article first published online: 17 JUN 2013 | DOI: 10.1002/dvdy.23995

  2. Art Pix

    1. Top of page
    2. Cover Image
    3. Art Pix
    4. Research Articles
    5. Patterns & Phenotypes
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      DD ArtPix

      Article first published online: 17 JUN 2013 | DOI: 10.1002/dvdy.23996

  3. Research Articles

    1. Top of page
    2. Cover Image
    3. Art Pix
    4. Research Articles
    5. Patterns & Phenotypes
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      On the role of intrinsic and extrinsic forces in early cardiac S-looping (pages 801–816)

      Ashok Ramasubramanian, Quynh B. Chu-Lagraff, Takashi Buma, Kevin T. Chico, Meagan E. Carnes, Kyra R. Burnett, Sarah A. Bradner and Shaun S. Gordon

      Article first published online: 4 JUN 2013 | DOI: 10.1002/dvdy.23968

      Key Findings

      • The embryonic heart has no intrinsic capability to form an s-loop.
      • External forces supplied by the splanchnopleure and cervical flexure are necessary for cardiac s-loop formation.
      • Computer modeling can be used to study the forces involved in s-loop formation.
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      A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis (pages 817–831)

      Vida Senkus Melvin, Weiguo Feng, Laura Hernandez-Lagunas, Kristin Bruk Artinger and Trevor Williams

      Article first published online: 3 JUN 2013 | DOI: 10.1002/dvdy.23969

      Key Findings

      • Multiple genes targeted with Morpholinos result in zebrafish craniofacial defects.
      • Most phenotypes are p53 independent, others suggest specific interaction with the p53 pathway.
      • Zebrafish studies highlight connections with mouse and human facial development pathology.
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      Activation of canonical Wnt/β-catenin signaling stimulates proliferation in neuromasts in the zebrafish posterior lateral line (pages 832–846)

      Jeffery R. Head, Leah Gacioch, Matthew Pennisi and Jason R. Meyers

      Article first published online: 4 JUN 2013 | DOI: 10.1002/dvdy.23973

      Key Findings

      • Activation of Wnt signaling leads to significant increases in the number of proliferating progenitors in lateral line neuromasts post-deposition.
      • Wnt stimulation increases in proliferation lead to expansion of the neuromasts including a significant increase in the number of hair cells produced.
      • Wnt signaling is sufficient to trigger quiescent supporting cells to return to the cell cycle in more mature neuromasts.
      • Wnt signaling significantly increases the number of supporting cells that respond to hair cell loss by proliferating and leads to an increase in the number of regenerated hair cells.
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      Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord (pages 847–860)

      Subhra Prakash Hui, James R. Monaghan, S. Randal Voss and Sukla Ghosh

      Article first published online: 3 JUN 2013 | DOI: 10.1002/dvdy.23976

      Key Findings

      • Myelin associated factors (MAFs) are expressed in axolotl spinal cord during development and adulthood.
      • Both Nogo-A and NgR are expressed in neural progenitor cells during spinal cord regeneration.
      • In contrast to mammals these MAFs are permissive for CNS development and regeneration in axolotl.
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      Drosophila semaphorin2b is required for the axon guidance of a subset of embryonic neurons (pages 861–873)

      Mark M. Emerson, Jennifer B. Long and David Van Vactor

      Article first published online: 30 MAY 2013 | DOI: 10.1002/dvdy.23979

      Key Findings

      • Misexpression of the secreted semaphorin Sema-2b in neurons results in specific axon guidance phenotypes.
      • Both Sema-2b loss-of-function and misexpression phenotypes are congruent with a cell-autonomous role for Sema-2b.
      • Novel axon guidance phenotypes caused by Sema-2b loss-of-function mutations are characterized.
  4. Patterns & Phenotypes

    1. Top of page
    2. Cover Image
    3. Art Pix
    4. Research Articles
    5. Patterns & Phenotypes
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      Expression and function of scalloped during Drosophila development (pages 874–885)

      Kirsten A. Guss, Michael Benson, Nicholas Gubitosi, Karrie Brondell, Kendal Broadie and James B. Skeath

      Article first published online: 3 JUN 2013 | DOI: 10.1002/dvdy.23942

      Key Findings

      • Scalloped (SD) protein expression is characterized for the first time using an anti-SD antibody.
      • SD is expressed in the central and peripheral nervous systems, the musculature and the flight appendage primordia of the Drosophila embryo, and in the larval imaginal discs.
      • sd function is required for the correct innervation of the somatic muscles by the ventral unpaired median motor neurons.
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      Characterization of TGFβ signaling during tail regeneration in the leopard Gecko (Eublepharis macularius) (pages 886–896)

      Richard W.D. Gilbert, Matthew K. Vickaryous and Alicia M. Viloria-Petit

      Article first published online: 4 JUN 2013 | DOI: 10.1002/dvdy.23977

      Key Findings

      • Large induction of phosphorylated SMAD2 in blastema cells indicates robust activation of TGFβ/activin pathway during regeneration.
      • TGFβ1 expression absent in early regenerate tissue and activin-βA mRNA significantly upregulated in regenerate tissue suggestive of dynamic ligand expression patterns.
      • EMT transcription factors Snail1 and Snail2 significantly upregulated in regenerating tissue.
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      Spatiotemporal expression of zic genes during vertebrate inner ear development (pages 897–908)

      Andrew P. Chervenak, Ibrahim S. Hakim and Kate F. Barald

      Article first published online: 30 MAY 2013 | DOI: 10.1002/dvdy.23978

      Key Findings

      • Zic genes are expressed in the dorsal neural tube and mesenchyme surrounding the developing inner ear in both mouse and chick.
      • Zic genes are not expressed in the otic epithelium of either mouse or chick.
      • Differential spatiotemporal expression of Zic genes (Zic1–5 in mouse, Zic1–4 in chick) is seen during inner ear development.

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