Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development (pages 964–975)
Beata Filipek-Górniok, Katarina Holmborn, Tatjana Haitina, Judith Habicher, Marta Bastos Oliveira, Charlotte Hellgren, Inger Eriksson, Lena Kjellén, Johan Kreuger and Johan Ledin
Article first published online: 18 JUN 2013 | DOI: 10.1002/dvdy.23981
- The zebrafish genes csgalnact1, csgalnact2, chsy1, chsy3, chpf2, chpfa, and chpfb are orthologues to the human genes that mediate CS/DS polymerization.
- Chordate CS/DS glycosyltransferases may be divided into the CSGALNACT, CHSY, and CHPF families.
- Sites of high CS/DS production in zebrafish embryos are characterized by the overlapping expression of multiple CS/DS producing glycosyltransferases.
- The content of CS/DS per fish is massively increased during zebrafish larval development whereas the heparan sulfate content gets stabilized around 48 hpf.