Initiation of primary myogenesis in amniote limb muscles (pages 1043–1055)
Antonio S.J. Lee, John Harris, Michael Bate, Krishnaswamy Vijayraghavan, Lorryn Fisher, Shahragim Tajbakhsh and Marilyn Duxson
Version of Record online: 22 JUL 2013 | DOI: 10.1002/dvdy.23998
- Primary myogenesis in vivo is a critical stage for patterning muscle, but is poorly understood.
- In rat and mouse limb buds it occurs in muscle masses expressing Pax3 protein, but before Pax7 protein is detected.
- The first primary myotubes are elongate, mononucleated myocytes, and they appear before cleavage of the muscle masses.
- Multinucleation occurs approximately a day later, synchronous with appearance of Pax7 protein in the muscle masses.