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Developmental Dynamics

Cover image for Vol. 243 Issue 4

April 2014

Volume 243, Issue 4

Pages C1–C1, 509–620

  1. Cover Image

    1. Top of page
    2. Cover Image
    3. Research Articles
    4. Patterns & Phenotypes
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      The Role of Sdf-1α signaling in Xenopus laevis somite morphogenesis (page C1)

      Marisa A. Leal, Sarah R. Fickel, Armbien Sabillo, Julio Ramirez, Hernando Martínez Vergara, Ceazar Nave, Daniel Saw and Carmen R. Domingo

      Version of Record online: 25 MAR 2014 | DOI: 10.1002/dvdy.24046

      Key Findings

      • Knockdown of sdf-1α and cxcr4 disrupts somite rotation and myotome alignment in X. laevis.
      • Knockdown of sdf-1α and cxcr4 expression leads to a significant decrease in β-dystroglycan and laminin expression.
      • Knockdown of sdf-1α decreases the level of activated RhoA.
      • Sdf-1α signaling is important for intersomitic boundary formation.
      • Sdf-1α signaling plays a conserved role in regulating somite rotation in zebrafish and X. laevis, but the mechanism underlying this process is quite distinct.
  2. Research Articles

    1. Top of page
    2. Cover Image
    3. Research Articles
    4. Patterns & Phenotypes
    1. You have free access to this content
      The Role of Sdf-1α signaling in Xenopus laevis somite morphogenesis (pages 509–526)

      Marisa A. Leal, Sarah R. Fickel, Armbien Sabillo, Julio Ramirez, Hernando Martínez Vergara, Ceazar Nave, Daniel Saw and Carmen R. Domingo

      Version of Record online: 19 DEC 2013 | DOI: 10.1002/dvdy.24092

      Key Findings

      • Knockdown of sdf-1α and cxcr4 disrupts somite rotation and myotome alignment in X. laevis.
      • Knockdown of sdf-1α and cxcr4 expression leads to a significant decrease in β-dystroglycan and laminin expression.
      • Knockdown of sdf-1α decreases the level of activated RhoA.
      • Sdf-1α signaling is important for intersomitic boundary formation.
      • Sdf-1α signaling plays a conserved role in regulating somite rotation in zebrafish and X. laevis, but the mechanism underlying this process is quite distinct.
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      Developmental expression and role of Kinesin Eg5 during Xenopus laevis embryogenesis (pages 527–540)

      Juan P. Fernández, Tristán H. Agüero, Guillermo A. Vega López, Gabriela Marranzino, Santiago Cerrizuela and Manuel J. Aybar

      Version of Record online: 19 DEC 2013 | DOI: 10.1002/dvdy.24094

      Key Findings

      • We show the kinesin eg5 expression pattern during Xenopus early embryogenesis.
      • The eg5 gene is required for neural crest early specification, maintenance, migration and derivatives formation.
      • A new role for eg5 in cell fate decisions and specification rather than in cell proliferation and apoptosis regulatory events is demonstrated.
      • eg5 has a hierarchical relationship with members of the Indian Hedgehog pathway and its activity is located downstream of ihh and upstream of the effector gli3.
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      Embryonic craniofacial bone volume and bone mineral density in Fgfr2+/P253R and nonmutant mice (pages 541–551)

      Christopher J. Percival, Yuan Huang, Ethylin Wang Jabs, Runze Li and Joan T. Richtsmeier

      Version of Record online: 7 FEB 2014 | DOI: 10.1002/dvdy.24095

      Key findings

      • Quantifying multiple aspects of gross bone phenotype can provide a more complete understanding of typical bone development and the influence of known mutations.
      • Within the mouse skull, endochondrally ossified bones increase in relative density quickly during the prenatal period, while intramembranously ossified bones do not.
      • There appear to be shifts in the influence of the FGFR2 P253R mutation on craniofacial bone volume during both the prenatal and postnatal periods.
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      FGF7 signals are relayed to autocrine EGF family growth factors to induce branching morphogenesis of mouse salivary epithelium (pages 552–559)

      Hayashi Kera, Satoshi Yuki and Hiroyuki Nogawa

      Version of Record online: 19 DEC 2013 | DOI: 10.1002/dvdy.24097

      Key findings

      • A combination of FGF7 + LPA induced branching morphogenesis of submandibular epithelium more extensively than FGF7 only.
      • Three members of the EGF family were expressed in FGF7-stimulated submandibular epithelium, and were able to induce epithelial branching morphogenesis in association with LPA.
      • An inhibitor of EGF signaling or shaking cultures impaired epithelial branching morphogenesis induced by FGF7 + LPA.
      • Autocrine EGF family growth factors are involved in epithelial branching morphogenesis induced by FGF7 + LPA.
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      Soluble form of FGFR2 with S252W partially prevents craniosynostosis of the apert mouse model (pages 560–567)

      Jumpei Morita, Masataka Nakamura, Yukiho Kobayashi, Chu-Xia Deng, Noriko Funato and Keiji Moriyama

      Version of Record online: 19 DEC 2013 | DOI: 10.1002/dvdy.24099

      Key Findings

      • We generated an Fgfr2+/S252W Apert mouse model expressing a soluble form of FGFR2S252W.
      • The soluble form of FGFR2S252W partially rescued Apert syndrome-like phenotypes in vivo.
      • Fgfr2+/S252W mice exhibited ectopic bone and thickened cartilage formation in interfrontal sutures.
  3. Patterns & Phenotypes

    1. Top of page
    2. Cover Image
    3. Research Articles
    4. Patterns & Phenotypes
    1. You have free access to this content
      Selective accumulation of germ-line associated gene products in early development of the sea star and distinct differences from germ-line development in the sea urchin (pages 568–587)

      Tara Fresques, Vanesa Zazueta-Novoa, Adrian Reich and Gary M. Wessel

      Version of Record online: 25 DEC 2013 | DOI: 10.1002/dvdy.24038

      Key findings

      • Sea stars have highly conserved germ line factors.
      • These factors are expressed in patterns that suggest the germ line forms from the posterior enterocoel.
      • The overall data supports the contention that the sea star uses an inductive mechanism of germ line determination, distinct from its near relative, the sea urchin.
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      Spatiotemporal expression pattern of Myt/NZF family zinc finger transcription factors during mouse nervous system development (pages 588–600)

      Fumio Matsushita, Toshiki Kameyama, Yuzo Kadokawa and Tohru Marunouchi

      Version of Record online: 19 DEC 2013 | DOI: 10.1002/dvdy.24091

      Key findings

      • Myt/NZF family genes are expressed over a wide area in almost all regions of the developing nervous system, and temporal expression of each Myt/NZF family transcript is regulated during neurogenesis.
      • NZF-1 is expressed last among the Myt/NZF family genes in post-mitotic neurons in almost all regions of developing nervous tissues.
      • Expression of NZF-2 and NZF-3 is restricted during neuronal differentiation. NZF-3 is initially expressed in neuronal cells that have just completed proliferation and differentiation. NZF-2 is expressed in neuronal cells a little earlier than NZF-3.
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      Small leucine-rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development (pages 601–611)

      Loren E. Dupuis and Christine B. Kern

      Version of Record online: 4 JAN 2014 | DOI: 10.1002/dvdy.24100

      Key Findings

      • Decorin is prominently expressed in maturing and adult cardiac valve cusps.
      • Biglycan expression is localized to regions of elastin synthesis in the arterial wall and cardiac valves.
      • Fibromodulin shows restricted expression in the annulus and valve hinge of the murine heart.
      • Lumican expression increases throughout postnatal cardiac valve maturation.
      • SLRP expression overlaps with regions of TGFβ signaling in the murine heart.
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      Anterior-posterior regionalized gene expression in the Ciona notochord (pages 612–620)

      Wendy Reeves, Rachel Thayer and Michael Veeman

      Version of Record online: 27 DEC 2013 | DOI: 10.1002/dvdy.24101

      Key Findings

      • Gene expression in the Ciona notochord is not always spatially uniform
      • CTGF is expressed stochastically in a subset of notochord cells
      • ERM is differentially expressed in the two notochord lineages
      • A calmodulin-like gene is more strongly expressed at the tips of the notochord
      • TGF-β is expressed in a posterior to anterior gradient

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