The Role of Sdf-1α signaling in Xenopus laevis somite morphogenesis (page C1)
Marisa A. Leal, Sarah R. Fickel, Armbien Sabillo, Julio Ramirez, Hernando Martínez Vergara, Ceazar Nave, Daniel Saw and Carmen R. Domingo
Version of Record online: 25 MAR 2014 | DOI: 10.1002/dvdy.24046
- Knockdown of sdf-1α and cxcr4 disrupts somite rotation and myotome alignment in X. laevis.
- Knockdown of sdf-1α and cxcr4 expression leads to a significant decrease in β-dystroglycan and laminin expression.
- Knockdown of sdf-1α decreases the level of activated RhoA.
- Sdf-1α signaling is important for intersomitic boundary formation.
- Sdf-1α signaling plays a conserved role in regulating somite rotation in zebrafish and X. laevis, but the mechanism underlying this process is quite distinct.