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Developmental Dynamics

Cover image for Vol. 243 Issue 5

May 2014

Volume 243, Issue 5

Pages C1–C1, 621–738

  1. Cover Image

    1. Top of page
    2. Cover Image
    3. Perspective
    4. Research Articles
    5. Techniques
    6. Patterns & Phenotypes
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      Induction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit (page C1)

      Marek Pacal and Rod Bremner

      Version of Record online: 17 APR 2014 | DOI: 10.1002/dvdy.24047

      Key findings

      • POU4F2 (BRN3B) is induced after CCND1 and VSX2 down-regulation, but before cell cycle exit in both early human and mouse retinal progenitors, but gradually shifts to postmitotic induction at later times.
      • Human POU4F2 and CALB2 are co-induced in progenitors, whereas ISL1 appears after cell cycle exit, but murine Isl1 and Calb2 show the reverse pattern.
      • KI67, PCNA, and MCM2 are maintained in both human and murine postmitotic ganglion cells and KI67 extinction matches the arrival of ganglion cells at their destination and the induction of POU4F1 (BRN3A).
      • Pou4f2 induction frequency and timing in S-phase supports the notion of biased ganglion cell progenitors early in retinal development.
  2. Perspective

    1. Top of page
    2. Cover Image
    3. Perspective
    4. Research Articles
    5. Techniques
    6. Patterns & Phenotypes
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      Rebirth of human embryology (pages 621–628)

      Raymond F. Gasser, R. John Cork, Brian J. Stillwell and David T. McWilliams

      Version of Record online: 27 FEB 2014 | DOI: 10.1002/dvdy.24110

      Key findings

      • Brief history of human embryonic development
      • Features of the Virtual Human Embryo DREM (VHE) website
      • VHE features on The Endowment for Human Development (EHD) website
  3. Research Articles

    1. Top of page
    2. Cover Image
    3. Perspective
    4. Research Articles
    5. Techniques
    6. Patterns & Phenotypes
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      Tbx4 interacts with the short stature homeobox gene Shox2 in limb development (pages 629–639)

      Anne Glaser, Ripla Arora, Sandra Hoffmann, Li Li, Norbert Gretz, Virginia E. Papaioannou and Gudrun A. Rappold

      Version of Record online: 28 JAN 2014 | DOI: 10.1002/dvdy.24104

      Key findings

      • Tbx4 expression is increased in the developing forelimbs of Shox2-deficient mice.
      • Tbx4 regulates Shox2 expression in developing fore- and hindlimbs, suggesting Shox2 as a feedback modulator of Tbx4.
      • Tbx4 binds to the Shox2 promoter.
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      Essential role for the SLK protein kinase in embryogenesis and placental tissue development (pages 640–651)

      Khalid N. Al-Zahrani, Prabhjot Sekhon, Daniel R. Tessier, Julien Yockell-Lelievre, Benjamin R. Pryce, Kyla D. Baron, Grant A. Howe, Roshan K. Sriram, Kate Daniel, Marlene Mckay, Vivian Lo, Jennifer Quizi, Christina L. Addison, Andrée Gruslin and Luc A. Sabourin

      Version of Record online: 28 JAN 2014 | DOI: 10.1002/dvdy.24106

      Key Findings

      • SLK is expressed throughout the developing mouse embryo.
      • Absence of SLK results embryonic defects predominantly in the myogenic and neurogenic compartments.
      • SLK deletion results in impaired vascularization and placental defects.
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      Left atrial ligation alters intracardiac flow patterns and the biomechanical landscape in the chick embryo (pages 652–662)

      William J. Kowalski, Nikola C. Teslovich, Prahlad G. Menon, Joseph P. Tinney, Bradley B. Keller and Kerem Pekkan

      Version of Record online: 27 JAN 2014 | DOI: 10.1002/dvdy.24107

      Key findings

      • Blood returning from different venous sites form multiple, distinct intracardiac streams through the embryonic chick heart.
      • Intracardiac flow patterns are altered acutely post left atrial ligation intervention.
      • After left atrial ligation, the intracardiac position of blood streams from the right common cardinal vein and right vitelline vein shift significantly toward the ventral wall of the ventricle in vivo.
      • In silico models of the normal and left atrial ligated embryonic heart show reduced wall shear stress at the left atrioventricular canal and left side of the common ventricle, sites commonly affected in hypoplastic left heart syndrome.
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      Fgfr signaling is required as the early eye field forms to promote later patterning and morphogenesis of the eye (pages 663–675)

      K. Atkinson-Leadbeater, C.L. Hehr and S. Mcfarlane

      Version of Record online: 24 FEB 2014 | DOI: 10.1002/dvdy.24113

      Key Findings

      • Fgfs act within an early critical period, as the eye field forms, to regulate eye morphogenesis.
      • Inhibition of Fgfr signaling at eye field stages causes coloboma due to a loss of ventronasal retina.
      • Fgf signaling at the eye field stage is required to position gene expression along the dorsoventral axis of the neural retina.
      • An early Fgf signal promotes the development of the periocular mesenchyme in the region adjacent to the ventronasal retina.
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      uPA-uPAR molecular complex is involved in cell signaling during neuronal migration and neuritogenesis (pages 676–689)

      Noelia Lino, Luciano Fiore, Melina Rapacioli, Luisa Teruel, Vladimir Flores, Gabriel Scicolone and Viviana Sánchez

      Version of Record online: 19 FEB 2014 | DOI: 10.1002/dvdy.24114

      Key Findings

      • uPA promotes neuronal migration and neuritogenesis by a combined proteolytic and nonproteolytic mechanism.
      • α5β1 integrin interacts with uPAR in postmitotic neurons.
      • uPA-uPAR complex promotes FAK activation.
      • uPAR binding to uPA induces cytoskeletal rearrangement in postmitotic neurons.
  4. Techniques

    1. Top of page
    2. Cover Image
    3. Perspective
    4. Research Articles
    5. Techniques
    6. Patterns & Phenotypes
    1. You have free access to this content
      Combination of in ovo electroporation and time-lapse imaging to study migrational events in chicken embryos (pages 690–698)

      Maryna Masyuk, Gabriela Morosan-Puopolo, Beate Brand-Saberi and Carsten Theiss

      Version of Record online: 24 FEB 2014 | DOI: 10.1002/dvdy.24109

      Key findings

      • New appropriate technologies are required to investigate cell migration in all its complexity.
      • We combine in ovo electroporation of cultured chicken embryos with the use of tissue slice culture and state-of-the-art imaging techniques, such as confocal laser scanning microscopy or spinning disc confocal microscopy.
      • The conditions and parameters used in this study allow long-term imaging for up to 24 hr.
  5. Patterns & Phenotypes

    1. Top of page
    2. Cover Image
    3. Perspective
    4. Research Articles
    5. Techniques
    6. Patterns & Phenotypes
    1. You have free access to this content
      Cardiovascular ATIP (Angiotensin receptor type 2 interacting protein) expression in mouse development (pages 699–711)

      Karin Bundschu and Kai Schuh

      Version of Record online: 22 JAN 2014 | DOI: 10.1002/dvdy.24102

      Key findings

      • ATIP is strongly expressed in the developing cardiovascular system of mice.
      • ATIP is expressed in the developing eye and limb buds.
      • ATIP isoform 3 expression is restricted to neural development.
      • ATIP expression is not always correlated to AT2 expression during mouse development.
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      Induction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit (pages 712–729)

      Marek Pacal and Rod Bremner

      Version of Record online: 27 JAN 2014 | DOI: 10.1002/dvdy.24103

      Key findings

      • POU4F2 (BRN3B) is induced after CCND1 and VSX2 down-regulation, but before cell cycle exit in both early human and mouse retinal progenitors, but gradually shifts to postmitotic induction at later times.
      • Human POU4F2 and CALB2 are co-induced in progenitors, whereas ISL1 appears after cell cycle exit, but murine Isl1 and Calb2 show the reverse pattern.
      • KI67, PCNA, and MCM2 are maintained in both human and murine postmitotic ganglion cells and KI67 extinction matches the arrival of ganglion cells at their destination and the induction of POU4F1 (BRN3A).
      • Pou4f2 induction frequency and timing in S-phase supports the notion of biased ganglion cell progenitors early in retinal development.
    3. You have free access to this content
      Expression of actin-binding proteins and requirement for actin-depolymerizing factor in chick neural crest cells (pages 730–738)

      Katie L. Vermillion, Kevin A. Lidberg and Laura S. Gammill

      Version of Record online: 28 JAN 2014 | DOI: 10.1002/dvdy.24105

      Key Findings

      • DCX, TPM-1 and ADF mRNA are expressed in premigratory and migratory neural crest cells.
      • DCX, TPM-1 and ADF exhibit distinct localization in migratory neural crest cells.
      • Expression of the neural crest transcription factor Sox10 requires ADF.
      • ADF is minimally important for chick neural crest migration.

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