R-spondins/Lgrs expression in tooth development (pages 844–851)
Maiko kawasaki, Thantrira Porntaveetus, Katsushige Kawasaki, Shelly Oommen, Yoko Otsuka-Tanaka, Mitsue Hishinuma, Takato Nomoto, Takeyasu Maeda, Keiyo Takubo, Toshio Suda, Paul T. Sharpe and Atsushi Ohazama
Article first published online: 24 MAR 2014 | DOI: 10.1002/dvdy.24124
- The role of R-spondin/Lgr signaling in tooth development remains unclear.
- We first carried out comparative in situ hybridization analysis of R-spondins and Lgrs, and identified their dynamic spatio-temporal expression in murine odontogenesis.
- We further examined tooth development in R-spondin2 mutant mice, and although molars and incisors exhibited no significant abnormalities, supernumerary teeth were observed in the diastema.