This article is a US Government work and, as such, is in the public domain in the United States of America.
Rx-Cre, a tool for inactivation of gene expression in the developing retina †
Article first published online: 18 JUL 2006
Published 2006 Wiley-Liss, Inc.
Volume 44, Issue 8, pages 361–363, August 2006
How to Cite
Swindell, E. C., Bailey, T. J., Loosli, F., Liu, C., Amaya-Manzanares, F., Mahon, K. A., Wittbrodt, J. and Jamrich, M. (2006), Rx-Cre, a tool for inactivation of gene expression in the developing retina . Genesis, 44: 361–363. doi: 10.1002/dvg.20225
- Issue published online: 1 AUG 2006
- Article first published online: 18 JUL 2006
- Manuscript Accepted: 13 JUN 2006
- Manuscript Received: 23 FEB 2006
- NIH/NEI. Grant Numbers: EY12505, EY12163, T32 EY07102
Rx is a homeobox-containing gene that is critical for vertebrate eye development. Its expression domain delineates a field of cells from which the retina and the ventral hypothalamus develop. The 5′ upstream regulatory sequences of the medaka fish Rx gene are functionally conserved during evolution to a degree that they direct gene expression into the Rx-expressing field of cells in mice. Using these sequences, we made a Cre line that can be used for inactivation of gene expression in the developing retina. genesis 44:361–363, 2006. Published 2006 Wiley-Liss, Inc.