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Keywords:

  • Cre;
  • homeobox;
  • hypothalamus;
  • medaka;
  • retina;
  • Rx

Abstract

Rx is a homeobox-containing gene that is critical for vertebrate eye development. Its expression domain delineates a field of cells from which the retina and the ventral hypothalamus develop. The 5′ upstream regulatory sequences of the medaka fish Rx gene are functionally conserved during evolution to a degree that they direct gene expression into the Rx-expressing field of cells in mice. Using these sequences, we made a Cre line that can be used for inactivation of gene expression in the developing retina. genesis 44:361–363, 2006. Published 2006 Wiley-Liss, Inc.