Evolution of the neural crest viewed from a gene regulatory perspective
Article first published online: 10 NOV 2008
Copyright © 2008 Wiley-Liss, Inc.
Special Issue: Chordate Origins and Evolution
Volume 46, Issue 11, pages 673–682, November 2008
How to Cite
Sauka-Spengler, T. and Bronner-Fraser, M. (2008), Evolution of the neural crest viewed from a gene regulatory perspective. Genesis, 46: 673–682. doi: 10.1002/dvg.20436
- Issue published online: 10 NOV 2008
- Article first published online: 10 NOV 2008
- Manuscript Accepted: 12 AUG 2008
- Manuscript Revised: 18 JUL 2008
- Manuscript Received: 14 MAY 2008
- neural crest;
- gene regulation;
Neural crest cells are a vertebrate innovation and form a wide variety of embryonic cell types as diverse as peripheral neurons and facial skeleton. They undergo complex migration and differentiation processes from their site of origin in the developing central nervous system to their final destinations in the periphery. In this review, we summarize recent data on the current formulation of a gene regulatory network underlying neural crest formation and its roots at the base of the vertebrate lineage. Analyzing neural crest formation from a gene regulatory viewpoint provides insights into both the developmental mechanisms and evolutionary origins of this vertebrate-specific cell type. genesis 46:673–682, 2008. © 2008 Wiley-Liss, Inc.