A novel null allele of mouse Dscam survives to adulthood on an inbred C3H background with reduced phenotypic variability

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Abstract

Rod bipolar cells (green; PKCa+), a subset of retinal bipolar cells (red; CHX10+) span the two synaptic layers of the mouse retina, Nuclei in the three nuclear layers of the mouse retina are blue (Hoechst stain). A new mutant mouse allele of Down syndrome cell adhesion molecule (Dscam) was used to study the role of this gene in synaptic lamination of the mouse retina. See the article by Fuerst et al. in this issue.

Ancillary