Mouse resources for craniofacial research
Article first published online: 1 APR 2011
Copyright © 2011 Wiley-Liss, Inc.
Special Issue: Special Issue on Craniofacial Development
Volume 49, Issue 4, pages 190–199, April 2011
How to Cite
Murray, S. A. (2011), Mouse resources for craniofacial research. Genesis, 49: 190–199. doi: 10.1002/dvg.20722
- Issue published online: 14 APR 2011
- Article first published online: 1 APR 2011
- Accepted manuscript online: 21 JAN 2011 12:41PM EST
- Manuscript Accepted: 16 JAN 2011
- Manuscript Revised: 6 JAN 2011
- Manuscript Received: 15 DEC 2010
- NIH. Grant Numbers: DE020052, DE019451, RR026117
The mouse, as a genetically defined and easily manipulated model organism, has played a critical role in unraveling the mechanisms of craniofacial development and dysmorphology. While numerous gene knockout strains that display craniofacial abnormalities and essential recombinase tool strains with craniofacial-specific expression have been generated, many are absent from public repositories. Large-scale, international resource-generating initiatives promise to address this concern, providing a comprehensive set of targeted mutations and a suite of new Cre driver strains. In addition, panels of genetically defined strains provide tools to dissect the multigenic, complex nature of craniofacial development, adding to the foundation of information gained from single gene studies. Continued progress will require awareness and access to these essential mouse resources. In this review, current mouse resources, large-scale efforts, and potential future directions will be outlined and discussed. genesis 49:190–199, 2011. © 2011 Wiley-Liss, Inc.