Time-lapse imaging of neural development: Zebrafish lead the way into the fourth dimension

Authors

  • Sandra Rieger,

    1. Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California
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    • Sandra Rieger and Fang Wang contributed equally to this work

  • Fang Wang,

    1. Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California
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    • Sandra Rieger and Fang Wang contributed equally to this work

  • Alvaro Sagasti

    Corresponding author
    1. Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California
    • Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA
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Abstract

Time-lapse imaging is often the only way to appreciate fully the many dynamic cell movements critical to neural development. Zebrafish possess many advantages that make them the best vertebrate model organism for live imaging of dynamic development events. This review will discuss technical considerations of time-lapse imaging experiments in zebrafish, describe selected examples of imaging studies in zebrafish that revealed new features or principles of neural development, and consider the promise and challenges of future time-lapse studies of neural development in zebrafish embryos and adults. genesis 49:534–545, 2011. © 2011 Wiley-Liss, Inc.

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