Xenopus staufen2 is required for anterior endodermal organ formation
Version of Record online: 17 FEB 2012
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Xenopus Special Issue
Volume 50, Issue 3, pages 251–259, March 2012
How to Cite
Bilogan, C. K. and Horb, M. E. (2012), Xenopus staufen2 is required for anterior endodermal organ formation. Genesis, 50: 251–259. doi: 10.1002/dvg.22000
- Issue online: 2 MAR 2012
- Version of Record online: 17 FEB 2012
- Accepted manuscript online: 12 DEC 2011 01:49AM EST
- Manuscript Accepted: 1 DEC 2011
- Manuscript Revised: 29 NOV 2011
- Manuscript Received: 8 NOV 2011
- National Institutes of Health. Grant Number: DK077197
- RNA binding protein;
Defining the regulatory molecular networks involved in patterning the developing anterior endoderm is essential to understand how the pancreas, liver, stomach, and duodenum are discretely specified from each other. In this study, we analyzed the expression and function of the double-stranded RNA-binding protein Staufen2 in Xenopus laevis endoderm. We found that staufen2 was broadly expressed within the developing endoderm beginning at gastrulation becoming localized to the anterior endoderm at later stages. Through morpholino-mediated knockdown, we demonstrate that Staufen2 function is required for proper formation of the stomach, liver, and pancreas. We define that its function is required during gastrulation for proper patterning of the dorsal-ventral axis and that it acts to regulate expression of BMP signaling components. genesis 50:251–259, 2012. © 2012 Wiley Periodicals, Inc.