This project was made possible through a grant from Kong Christian den Tiendes Fond. Povl Munk-Jørgensen MD DMSc, The Danish Psychiatric Central Register, and the National Patient Register are acknowledged for technical assistance without which this study would not have been possible.
Fractures in patients with anorexia nervosa, bulimia nervosa, and other eating disorders—A nationwide register study†
Article first published online: 23 AUG 2002
Copyright © 2002 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 32, Issue 3, pages 301–308, November 2002
How to Cite
Vestergaard, P., Emborg, C., Støving, R. K., Hagen, C., Mosekilde, L. and Brixen, K. (2002), Fractures in patients with anorexia nervosa, bulimia nervosa, and other eating disorders—A nationwide register study. Int. J. Eat. Disord., 32: 301–308. doi: 10.1002/eat.10101
- Issue published online: 23 AUG 2002
- Article first published online: 23 AUG 2002
- Manuscript Accepted: 8 DEC 2001
- anorexia nervosa;
- bulimia nervosa;
- eating disorder;
To study fracture risk in patients with anorexia nervosa (AN), bulimia nervosa (BN), or eating disorders not otherwise specified (EDNOS).
Cohort study including all Danes diagnosed with AN (n = 2,149), BN (n = 1,294), or EDNOS (n = 942) between 1977 and 1998. Each patient was compared with three randomly drawn age- and gender-matched control subjects.
Fracture risk was increased in AN after diagnosis compared to controls (incidence rate ratio: 1.98, 95% CI: 1.60–2.44), but not before. The increased fracture risk persisted more than 10 years after diagnosis. A significant increase in fracture risk was found before diagnosis in BN (1.31, 95% CI: 1.04–1.64), with a trend towards an increase after diagnosis (1.44, 95% CI: 0.93–2.22). EDNOS patients had a significant increase in fracture risk before (1.39, 95% CI: 1.06–1.81) and after diagnosis (1.77, 95% CI: 1.25–2.51).
The increased fracture risk many years after diagnosis indicates permanent skeletal damage. © 2002 by Wiley Periodicals, Inc. Int J Eat Disord 32: 301–308, 2002.