Clinical and Research Forum: Review Article
Pathologic fear conditioning and anorexia nervosa: On the search for novel paradigms
Article first published online: 15 APR 2004
Copyright © 2004 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Special Issue: Featuring Abstracts from the 2004 International Conference on Eating Disorders
Volume 35, Issue 4, pages 504–508, May 2004
How to Cite
Strober, M. (2004), Pathologic fear conditioning and anorexia nervosa: On the search for novel paradigms. Int. J. Eat. Disord., 35: 504–508. doi: 10.1002/eat.20029
- Issue published online: 15 APR 2004
- Article first published online: 15 APR 2004
- Manuscript Accepted: 24 NOV 2003
- fear conditioning;
- anorexia nervosa;
- novel paradigms
Although eating disorders have been the focus of an unprecedented explosion of clinical interest in recent years, the etiology of anorexia nervosa remains elusive. It is hypothesized that an underlying causative mechanism involves a propensity to extreme fear conditioning and greater than normal resistance to its extinction. Knowledge accrued from recent behavioral, genetic, and neuroanatomic research on anxiety may yield further insight into the pathogenesis of anorexia nervosa, which can be subjected to experimental validation using objective measures of classical fear conditioning and functional neuroimaging of brain structures mediating fear behavior. © 2004 by Wiley Periodicals, Inc. Int J Eat Disord 35: 504–508, 2004.