The effects of bone therapy on tibial bone loss in young women with anorexia nervosa

Authors

  • Toshihiro Nakahara MD,

    Corresponding author
    1. Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima-City, Japan
    • Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, 8-35-1, Sakuragaoka, Kagoshima-City 890-8520, Japan
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  • Nobuatsu Nagai MD,

    1. Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima-City, Japan
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  • Muneki Tanaka MD,

    1. Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima-City, Japan
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  • Tetsuro Muranaga MD,

    1. Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima-City, Japan
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  • Shinya Kojima MD,

    1. Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima-City, Japan
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  • Shin-ichi Nozoe MD,

    1. Department of Clinical Psychology, Faculty of Human Studies, Shigakukan University, Kagoshima-City, Japan
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  • Tetsuro Naruo MD

    1. Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima-City, Japan
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Abstract

Objective

Osteoporosis is recognized as a common medical complication of anorexia nervosa (AN). The purpose of the current study was to investigate the recovery mechanism of osteoporosis in AN and the effect of medical treatment on the skeletal system.

Method

We conducted a randomized placebo-controlled study of the effects of etidronate and calcium and vitamin D on bone loss in 41 outpatients with the restricting type of AN (AN-R). We measured the tibial speed of sound (SOS) before and after 3 months of treatment.

Results

The bone mineral density (BMD) of the tibial SOS change in both the etidronate group and the calcium and vitamin D Group was significantly greater (p < .001) than in the control group. Urine-N-telopeptide cross-links of type I collagen (NTx) before and after treatment decreased significantly (p < .01) in the etidronate group.

Conclusion

These findings suggest that both etidronate and calcium and vitamin D are equally efficacious for reversing the degree of osteoporosis in patients with AN. © 2005 by Wiley Periodicals, Inc.

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