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The effects of bone therapy on tibial bone loss in young women with anorexia nervosa

  1. Toshihiro Nakahara MD1,*,
  2. Nobuatsu Nagai MD1,
  3. Muneki Tanaka MD1,
  4. Tetsuro Muranaga MD1,
  5. Shinya Kojima MD1,
  6. Shin-ichi Nozoe MD2,
  7. Tetsuro Naruo MD1

Article first published online: 17 OCT 2005

DOI: 10.1002/eat.20197

Issue

International Journal of Eating Disorders

International Journal of Eating Disorders

Volume 39, Issue 1, pages 20–26, January 2006

Additional Information

How to Cite

Nakahara, T., Nagai, N., Tanaka, M., Muranaga, T., Kojima, S., Nozoe, S.-i. and Naruo, T. (2006), The effects of bone therapy on tibial bone loss in young women with anorexia nervosa. Int. J. Eat. Disord., 39: 20–26. doi: 10.1002/eat.20197

Author Information

  1. 1

    Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima-City, Japan

  2. 2

    Department of Clinical Psychology, Faculty of Human Studies, Shigakukan University, Kagoshima-City, Japan

*Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, 8-35-1, Sakuragaoka, Kagoshima-City 890-8520, Japan

Publication History

  1. Issue published online: 12 DEC 2005
  2. Article first published online: 17 OCT 2005
  3. Manuscript Accepted: 6 FEB 2005

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REFERENCES

  • American Psychiatric Association. (1993). Practice guidance for eating disorders. American Journal of Psychiatry, 150, 207–228.
  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
  • Bachrach, L.K., Guido, D., Katzman, D., Litt, I.F., & Marcus, R. (1990). Decreased bone density in adolescent girls with anorexia nervosa. Pediatrics, 86, 440–447.
  • Bachrach, L.K., Katzman, D., Litt, I.F., Guido, D., & Marcus, R. (1991). Recovery from osteopenia in adolescent girls with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism, 72, 602–606.
  • Baeksgaard, L., Andersen, K.P., & Hyldstrup, L. (1988). Calcium and vitamin D supplementation increases spinal BMD in healthy, postmenopausal women. Osteoporosis International, 8, 255–260.
  • Baker, D., Roberts, R., & Towell, T. (2000). Factors predictive of bone mineral density in eating-disordered women: A longitudinal study. International Journal of Eating Disorders, 27, 29–35.
    Direct Link:
  • Biller, B.M.K., Saxe, V., Herzog, D.B., Rosenthal, D., Haizman, S., & Klibanski, A. (1989). Mechanism of osteoporosis in adult and adolescent women with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism, 68, 548–554.
  • Black, D.M., Cummings, S.R., Karpf, D.B., Cauley, J.A., Thompson, D.E., Nevitt, M.C., Bauer, D.C., Genant, K.E., Haskell, W.L., Marcus, R., Ott, S.M., Torner, J.C., Quandt, S.A., Reiss, T.F., & Ensrud, K.E. (1996). Randomized trial of effect of alendroate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet, 348, 1535–1541.
  • Brotman, A., & Stern, T. (1885). Osteoporosis and pathologic fractures in anorexia nervosa. American Journal of Psychiatry, 142, 495–496.
  • Caillot-Augusseau, A., Lafage-Proust, M., Margaillan, P., Vergely, N., Faure, S., Paillet, S., Lang, F., Alexandre, C., & Estour, B. (2000). Weight gain reverses bone turnover and restores circadian variation of bone resorption in anorexic patients. Clinical Endocrinology, 52, 113–121.
    Direct Link:
  • Chesnut, C.H. III, Bell, N.H., Clark G.S., Drinkwater, B.L., English, S.C., Johnson, C.C., Jr., Notelovitz, M., Rosen, C., & Cain, D.F. (1997). Hormone replacement therapy in post-menopausal women: Urinary N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. American Journal of Medicine, 102, 29–37.
  • Drake, W.M., & Brown, J.P. (2002). Use of phalangeal bone mineral density and multisite speed of sound conduction to monitor therapy with alendronate in postmenopausal women. Osteoporosis International, 13, 249–256.
  • Folders, A.J. (1995). Quantitative ultrasound of the tibia: A novel approach for assessment of bone status. Bone, 17, 363–367.
  • Gambacciani, M., Spinetti, A., Cappagli, B., Taponeco, B., Felipetto, R., Parrini, R., Cappelli, N., & Fioretti, P. (1993). Effects of ipriflavone administration on bone mass and metabolism in ovariectomized women. Journal of Endocrinological Investigation, 16, 333–337.
  • Gonnelli, S., Cepollaro, C., Pondrelli, C., Martini, S., Monaco, R., & Gennari, C. (1997). The usefulness of bone turnover in predicting the response to transdermal estrogen therapy in post-menopausal osteoporosis. Journal of Bone and Mineral Research, 12, 624–631.
    Direct Link:
  • Greenspan, S.L., Parker, R.A., Ferguson, L., Rosen, H.N., Maitland-Ramsey, L., & Karpf, D.B. (1998). Early changes in biochemical markers of bone turnover predict the long-term response to alendronate therapy in representative elderly women: A randomized clinical trial. Journal of Bone and Mineral Research, 13, 1431–1438.
    Direct Link:
  • Hamel, M.E., Sebaldt, R.J., Siminoski, K., Adachi, J.D., Papadimitrapoulos, E., Petrie, A., & Goldsmith, C.H., (2005). Influence of fracture risk and bone mineral density testing on the treatment of osteoporosis in two non-academic community centers. Osteoporosis International, 16, 208–215.
  • Hans, D., & Dargent-Molina, P. (1996). Ultrasonographic heel measurements to predict hip fracture in elderly women: The EPIDOS prospective study. Lancet, 348, 511–514.
  • Hans, D., Srivastav, S.K., & Singal, C. (1999). Does combining the results from multiple bone sites measured by a new quantitative ultrasound device improve discrimination of hip fracture? Journal of Bone and Mineral Research, 14, 644–651.
    Direct Link:
  • Herzog, D.B., & Copeland, P.M. (1985). Eating disorders. New England Journal of Medicine, 313, 295–303.
  • Hotta, M., Fukuda, I., Sato, K., Hizuka, N., Shibasaki, T., & Takano, K. (2000). The relationship between bone turnover and body weight, serum insulin-like growth factor (IGF) I, and serum IGF-binding protein levels in patients with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism, 85, 200–206.
  • Hotta, M., Shibasaki, T., Sato, K., & Demura, H. (1998). The importance of body weight history in the occurrence and recovery of osteoporosis in patients with anorexia nervosa: Evaluation by dual X-ray absorptiometry and bone metabolic markers. European Journal of Endocrinology, 139, 276–283.
  • Howat, P.M., Varner, L.M., Hegsted, M., Brewer, M.M., & Mills, G.Q. (1989). The effect of bulimia upon diet, body fat, bone density, and blood components. Journal of the American Dietetic Association, 89, 929–934.
  • Iketani, T., & Kiriike, N. (2003). Effect of menatetrenone (vitamin K) treatment on bone loss in patients with anorexia nervosa. Psychiatry Research, 177(3), 259–269.
  • Iketani, T., Kiriike, N., Nakanishi, S., & Nakasuji, T. (1995). Effects of weight gain and resumption of menses on reduced bone mineral density in patients with anorexia nervosa. Biological Psychiatry, 37, 521–527.
  • Kaplan, F.S., Pertschuk, M., Fallo, M., & Haddad, J. (1986). Osteoporosis and hip fracture in young women with anorexia nervosa. Clinical Orthopaedics and Related Research, 212, 250–254.
  • Kiriike, N., Iketani, T., Nakanishi, S., Nagata, T., Inoue, K., Okuno, M., Ochi, M., & Kawakita, Y. (1992). Reduced bone density and major hormones regulating calcium metabolism in anorexia nervosa. Acta Psychiatrica Scandinavica, 86, 358–363.
    Direct Link:
  • Klibanski, A., Biller, B.M.K., Schoenfeld, D.A., Herzog, D.B., & Saxe, V.C. (1995). The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism, 80, 898–904.
  • Kooh, S.W., & Noriega, E. (1996). Bone mass and soft tissure composition in adolescents with anorexia nervosa. Bone, 19, 181–188.
  • Kreipe, P.E., Hicks, D.G., Rosier, R.N., & Puzas, J.E. (1993). Preliminary findings on the effects of sex hormones on bone metabolism in anorexia nervosa. Journal of Adolescent Health, 14, 319–324.
  • Liberman, U.A., & Weiss, S.R. (1995). Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. New England Journal of Medicine, 333, 1437–1443.
  • Maugars, Y.M., Berthelot, J.M., Forestier, R., Mammar, N., Lalande, S., & Venisse, J. (1996). Follow-up of bone mineral density in 27 cases of anorexia nervosa. European Journal of Endocrinology, 135, 591–597.
  • Mehler, P.S. (2003). Osteoporosis in anorexia nervosa: Prevention and treatment. International Journal of Eating Disorders, 33, 113–126.
    Direct Link:
  • Miller, K.K., Grieco, K.A., Mulder, J., Grinspoon, S., Mickley, D., Yehezkel, R., Herzog, D.B., & Kliban-ski, A. (2004). Effects of risedronate on bone density in anorexia nervosa. Journal of Clinical Endocrinology and Metabolism, 89(8), 3903–3906.
  • Newman, M.M., & Halmi, K.A. (1989). Relationship of bone density to estradiol and cortisol in anorexia nervosa and bulimia. Psychiatry Research, 29, 105–112.
  • Ooms, M.E., Roos, J.C., Bezemer, P.D., van der Vijgh, W.J.F., Bouter, L.M., & Lips, P. (1995). Prevention of bone loss by vitamin D supplementation in elderly women: A randomized double-blind trial. Journal of Clinical Endocrinology and Metabolism, 80, 1052–1058.
  • Recker, R., Hinders, S., Davies, K.M., Heaney, R.P., Stegman, M.R., Lappe, J.M., & Kimmel, D.B. (1996). Correcting calcium nutritional deficiency prevents spine fractures in elderly women. Journal of Bone and Mineral Research, 11, 1961–1966.
    Direct Link:
  • Rico, H., Hernandez, E.R., Revilla, M., & Gomez-Castresana, F. (1992). Salmon calcitonin reduces vertebral fracture rate in postmenopausal crush fracture syndrome. Journal of Bone and Mineral Research, 16, 131–138.
  • Rigotti, N.A., Nussbaum, S.R., Herzog, D.B., & Neer, R.M. (1984). Osteoporosis in women with anorexia nervosa. New England Journal of Medicine, 311, 1601–1606.
  • Rodan, G.A., & Fleisch, H.A. (1996). Bisphosphonates: Mechanisms of action. Journal of Clinical Investigation, 97, 2692–2696.
  • Rosen, C.J., Chesnut, C.H., III, & Mallinak, N.J.S. (1997). The predictive value of biochemical markers of bone turnover for bone mineral density in early postmenopausal women treated with hormone replacement or calcium supplementation. Journal of Clinical Endocrinology and Metabolism, 82, 1904–1910.
  • Ruegsegger, P., Muller, A., Dambacher, M.A., Ittner, J., Willi, J., & Kopp, H.G. (1988). Knoochenabbau bei Patientinnen mit Anorexia nervosa. Schweizerische Medizinische Wochenschrift, [Bone loss in female patients with anorexia nervosa.] 118, 233–238.
  • Schott, A.M., Weill-Engerer, S., Hans, D., Duboeuf, F., Delmas, P.D., & Meunier, P.J. (1995). Ultrasound discriminates patients with hip fracture equally well as dual energy X-ray absorptiometry and independently of bone mineral density. Journal of Bone and Mineral Research, 10, 243–249.
    Direct Link:
  • Seeman, E., Szmukler, G.I., Formica, C., Tsalamandris, C., & Mestrovic, R. (1992). Osteoporosis in anorexia nervosa: The influence of peak bone density, bone loss, oral contraceptive use, and exercise. Journal of Bone and Mineral Research, 12, 1467–1474.
  • Storm, T., Thamsborg, G., Steiniche, T., Genant, H.K., & Sorensen, O.H. (1990). Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. New England Journal of Medicine, 322, 1265–1271.
  • Watts, N.B., Harris, S.T., Genant, H.K., Wasnich, R.D., Miller, P.D., Jackson, R.D., Licata, A.A., Ross, P., Woodson, G.C. III, & Yanover, M.J. (1990). Intermittent cyclical etidronate treatment of postmenopausal osteoporosis. New England Journal of Medicine, 323, 73–79.
  • Zipfel, S., Löwe, B., Reas, D.L., Deter, H.-C., & Herzog, W. (2000). Long-term prognosis in anorexia nervosa: Lessons from a 21-year follow-up study. Lancet, 355, 721–722.
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