Etiology of hypercholesterolemia in patients with anorexia nervosa
Article first published online: 21 JUN 2006
Copyright © 2006 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 39, Issue 7, pages 598–601, November 2006
How to Cite
Ohwada, R., Hotta, M., Oikawa, S. and Takano, K. (2006), Etiology of hypercholesterolemia in patients with anorexia nervosa. Int. J. Eat. Disord., 39: 598–601. doi: 10.1002/eat.20298
- Issue published online: 13 OCT 2006
- Article first published online: 21 JUN 2006
- Manuscript Accepted: 20 FEB 2006
- anorexia nervosa;
- cholesterol metabolism;
- cholesterol ester transfer protein activity
Hypercholesterolemia is common in patients with anorexia nervosa (AN) despite emaciation. The objective of this study was to clarify the mechanism of hypercholesterolemia in AN.
We measured serum lipids in 39 patients with AN and analyzed serum lipid profiles in the 24 patients in comparison with five age-matched controls.
Mean serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), ketone bodies, apolipoprotein (apo)-A1, B, C2, C3, E, and cholesterol ester transfer protein (CETP) activity were significantly higher in patients with AN than in controls. No significant difference in serum free fatty acid (FFA) levels was observed between patients with AN and controls. CETP was accelerated in patients with AN with hypercholesterolemia. No correlation was apparent between serum levels of cholesterol and thyroid hormones.
Serum levels of cholesterol, CETP, and apolipoproteins decreased after weight gain, indicating that cholesterol metabolism is accelerated in patients with AN with normal serum levels of FFA. © 2006 by Wiley Periodicals, Inc. Int J Eat Disord 2006