Mood change during weight restoration in patients with anorexia nervosa

Authors

  • Katharine G. Meehan MA,

    1. Department of Psychiatry, New York State Psychiatric Institute, Columbia College of Physicians and Surgeons, New York, New York
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  • Katharine L. Loeb PhD,

    1. Department of Psychiatry, Mount Sinai School of Medicine, New York, New York
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  • Christina A. Roberto BA,

    1. Department of Psychiatry, New York State Psychiatric Institute, Columbia College of Physicians and Surgeons, New York, New York
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  • Evelyn Attia MD

    Corresponding author
    1. Department of Psychiatry, New York State Psychiatric Institute, Columbia College of Physicians and Surgeons, New York, New York
    • Department of Psychiatry, New York State Psychiatric Institute, Columbia College of Physicians and Surgeons, New York, New York
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Abstract

Objective:

Although depression is known to co-occur with anorexia nervosa (AN), there are few clear studies of mood in the context of weight gain treatment without the use of medication.

Method:

Twenty-one patients admitted consecutively to an inpatient clinical research unit normalized weight to at least 90% of ideal body weight (IBW). Depression was assessed at admission and weight normalization (pre-discharge) with the Beck Depression Inventory (BDI).

Results:

Multivariate F tests showed BDI scores to be significantly improved across these two time points (BMI: F(2,20) = 166.58, p = 0.000; BDI: F(2,19) = 22.64, p = 0.000). Moreover, improvement in mood was also evident at partial weight restoration (80% IBW).

Conclusion:

Patients with AN undergoing nutritional rehabilitation and psychotherapy on an inpatient unit present with significant depressive symptoms as measured by the BDI, and, with weight restoration, demonstrate statistically significant improvement in mood symptoms without the use of adjunctive medication. Data at partial weight restoration suggest that these results cannot be explained by improved mood related to anticipation of discharge. © 2006 by Wiley Periodicals, Inc. Int J Eat Disord 2006

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