A history of human-like dieting alters serotonergic control of feeding and neurochemical balance in a rat model of binge-eating
Article first published online: 1 NOV 2006
Copyright © 2006 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 40, Issue 2, pages 136–142, March 2007
How to Cite
Chandler-Laney, P. C., Castañeda, E., Viana, J. B., Oswald, K. D., Maldonado, C. R. and Boggiano, M. M. (2007), A history of human-like dieting alters serotonergic control of feeding and neurochemical balance in a rat model of binge-eating. Int. J. Eat. Disord., 40: 136–142. doi: 10.1002/eat.20349
- Issue published online: 29 JAN 2007
- Article first published online: 1 NOV 2006
- Manuscript Accepted: 13 AUG 2006
- NIH. Grant Numbers: DK066007, PD30DK056336
- National Eating Disorders Association
- palatable food;
- nucleus accumbens;
This study replicated a model of stress-induced binge-eating in rats with a history of caloric restriction (HCR), tested their response to SSRI (fluoxetine) treatment, and explored changes in brain monoamine levels.
Young female rats with no-HCR/no-Stress, no-HCR/Stress, HCR/no-Stress, and HCR+Stress (binge-eating) were treated with fluoxetine. Post-mortem levels of serotonin, dopamine, and metabolites were assessed from brain regions key to feeding and reward.
A 3 mg/kg dose of fluoxetine without effect in the no-HCR groups suppressed intake of HCR groups, normalizing the binge-eating of HCR/Stress rats. No differences in monoamines were detected in the hypothalamus or tegmentum but a strong positive relationship between accumbens serotonin and dopamine turnover in no-HCR rats was absent in rats with HCR.
Despite lack of hunger, a history of human-like dieting alters serotonin function in ways suggesting consequences not only to feeding but also control of reward and mood that are dependent on dopamine/serotonin interactions. © 2006 by Wiley Periodicals, Inc. Int J Eat Disord 2006