Regional cerebral blood flow after recovery from anorexia or bulimia nervosa

Authors

  • Guido K. Frank MD,

    1. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    2. Department of Child and Adolescent Psychiatry, San Diego School of Medicine, University of California, San Diego, California
    Search for more papers by this author
  • Ursula F. Bailer MD,

    1. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    2. Department of Biological Psychiatry, University Hospital of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Search for more papers by this author
  • Carolyn C. Meltzer MD,

    1. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    2. Department of Radiology, Emory University Hospital, Atlanta, Georgia
    Search for more papers by this author
  • Julie C. Price PhD,

    1. Department of Radiology, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Search for more papers by this author
  • Chester A. Mathis PhD,

    1. Department of Radiology, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Search for more papers by this author
  • Angela Wagner MD,

    1. Department of Child and Adolescent Psychiatry and Psychotherapy, J.W. Goethe University, Frankfurt, Germany
    Search for more papers by this author
  • Carl Becker BS,

    1. Department of Radiology, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Search for more papers by this author
  • Walter H. Kaye MD

    Corresponding author
    1. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O'Hara Street, Pittsburgh, PA 15213
    Search for more papers by this author

Abstract

Objective:

Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN.

Method:

Eighteen control women (CW), 10 recovered restricting type AN, 8 recovered AN with a binging history, and 9 recovered BN participants without a history of AN were studied using positron emission tomography and [15O]water in order to assess rCBF.

Results:

Partial volume corrected rCBF values in cortical and subcortical brain regions were similar between groups. Neither current body mass index nor age correlated with rCBF values.

Conclusion:

The results from this study indicate that rCBF normalizes with long-term recovery. Thus, altered rCBF is unlikely to confound functional imaging studies in AN or BN after recovery. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2007.

Ancillary