Regular Article

Regional cerebral blood flow after recovery from anorexia or bulimia nervosa

  1. Guido K. Frank MD1,2,
  2. Ursula F. Bailer MD1,3,
  3. Carolyn C. Meltzer MD1,4,
  4. Julie C. Price PhD5,
  5. Chester A. Mathis PhD5,
  6. Angela Wagner MD6,
  7. Carl Becker BS5,
  8. Walter H. Kaye MD1,*

Article first published online: 24 MAY 2007

DOI: 10.1002/eat.20395

Issue

International Journal of Eating Disorders

International Journal of Eating Disorders

Volume 40, Issue 6, pages 488–492, September 2007

Additional Information

How to Cite

Frank, G. K., Bailer, U. F., Meltzer, C. C., Price, J. C., Mathis, C. A., Wagner, A., Becker, C. and Kaye, W. H. (2007), Regional cerebral blood flow after recovery from anorexia or bulimia nervosa. Int. J. Eat. Disord., 40: 488–492. doi: 10.1002/eat.20395

Author Information

  1. 1

    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

  2. 2

    Department of Child and Adolescent Psychiatry, San Diego School of Medicine, University of California, San Diego, California

  3. 3

    Department of Biological Psychiatry, University Hospital of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria

  4. 4

    Department of Radiology, Emory University Hospital, Atlanta, Georgia

  5. 5

    Department of Radiology, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

  6. 6

    Department of Child and Adolescent Psychiatry and Psychotherapy, J.W. Goethe University, Frankfurt, Germany

*Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O'Hara Street, Pittsburgh, PA 15213

Publication History

  1. Issue published online: 27 JUL 2007
  2. Article first published online: 24 MAY 2007
  3. Manuscript Accepted: 4 APR 2007

Funded by

  • NIMH. Grant Numbers: MH046001, MH042984, K05-MD01894, T32-MH18399
  • Price Foundation

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Keywords:

  • anorexia nervosa;
  • bulimia nervosa;
  • cerebral blood flow;
  • brain

Abstract

Objective:

Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN.

Method:

Eighteen control women (CW), 10 recovered restricting type AN, 8 recovered AN with a binging history, and 9 recovered BN participants without a history of AN were studied using positron emission tomography and [15O]water in order to assess rCBF.

Results:

Partial volume corrected rCBF values in cortical and subcortical brain regions were similar between groups. Neither current body mass index nor age correlated with rCBF values.

Conclusion:

The results from this study indicate that rCBF normalizes with long-term recovery. Thus, altered rCBF is unlikely to confound functional imaging studies in AN or BN after recovery. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2007.

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