Activities of respiratory chain complexes in isolated platelets in females with anorexia nervosa
Version of Record online: 21 JUN 2007
Copyright © 2007 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 40, Issue 7, pages 659–663, November 2007
How to Cite
Böhm, M., Papezova, H., Hansikova, H., Wenchich, L. and Zeman, J. (2007), Activities of respiratory chain complexes in isolated platelets in females with anorexia nervosa. Int. J. Eat. Disord., 40: 659–663. doi: 10.1002/eat.20403
- Issue online: 26 SEP 2007
- Version of Record online: 21 JUN 2007
- Manuscript Accepted: 6 MAY 2007
- Unknown funding agency. Grant Numbers: MSM 0021620806, MSM 0021620849
- anorexia nervosa;
- respiratory chain complexes
A broad spectrum of endocrine and biochemical disturbances was observed in patients with anorexia nervosa. In addition, metabolic changes may concern the efficiency of mitochondrial energy generating system. In our study we analyzed the activities of respiratory chain complexes in females with anorexia nervosa.
The activities of respiratory chain complexes I, II, IV, I + III, and citrate synthase serving as the control enzyme were measured spectrophotometrically in isolated platelets in 36 females with anorexia nervosa (BMI 15 ± 1.7) at the age 18–35 years and in 37 age related female controls (BMI 21 ± 2.2).
In females with anorexia nervosa, the activities of respiratory chain complexes I and II in isolated platelets were significantly higher in comparison with controls. No differences were found in the activities of complexes IV and I + III and citrate synthase.
Our results suggest higher efficiency of some respiratory chain complexes in platelets in females with anorexia nervosa. © 2007 by Wiley Periodicals, Inc.