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Keywords:

  • baclofen;
  • binge eating;
  • bulimia nervosa;
  • eating disorder;
  • addiction;
  • clinical trial

Abstract

Objective:

Baclofen is a GABA-B agonist that may be useful in the treatment of substance use disorders, and also reduces ‘binge-like’ eating in rodents. We hypothesized that baclofen might be effective in reducing binge eating episodes in binge eating disorder (BED) and bulimia nervosa (BN).

Method:

Seven women with BED (n = 4) or BN (n = 3) took baclofen (60 mg/day) for 10 weeks.

Results:

Six out of seven patients completed the full 10-week trial. Five out of seven participants (3 BED; 2 BN) demonstrated 50% or greater reduction of frequency of binge eating from beginning to end of the study. Three out of seven participants (2 BED; 1 BN) were free of binge eating at study end. Four out of seven participants elected to continue baclofen at study end. Baclofen was well tolerated by the participants.

Conclusion:

In this open-label trial, baclofen was associated with decreased binge eating frequency in patients with BED and BN. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2007