Familiality and heritability of binge eating disorder: Results of a case-control family study and a twin study
Article first published online: 19 DEC 2007
Copyright © 2007 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 41, Issue 2, pages 174–179, March 2008
How to Cite
Javaras, K. N., Laird, N. M., Reichborn-Kjennerud, T., Bulik, C. M., Pope, H. G. and Hudson, J. I. (2008), Familiality and heritability of binge eating disorder: Results of a case-control family study and a twin study. Int. J. Eat. Disord., 41: 174–179. doi: 10.1002/eat.20484
- Issue published online: 20 FEB 2008
- Article first published online: 19 DEC 2007
- Manuscript Accepted: 8 AUG 2007
- binge eating disorder;
- binge eating;
- case-control family study;
- twin study;
- familial aggregation;
To estimate the familiality and heritability of binge eating disorder (BED).
We used a new ACE structural equation model to estimate heritability from a case-control family study of BED conducted in the Boston area. The sample consisted of 150 overweight/obese probands with lifetime BED by DSM-IV criteria, 150 overweight/obese probands without lifetime BED, and 888 of their first-degree relatives. We compared our findings with those from a study of binge eating (in the absence of compensatory behaviors) among 7,831 Norwegian twins.
The prevalence of BED differed by sex and by age. In the case-control family study, BED was found to aggregate in families, and heritability was estimated as 57% (CI: 30–77%). Including shared environment did not substantially improve the model's fit, nor did allowing sex-specific heritability. Findings from the twin study were similar.
BED appears to aggregate in families and have a significant genetic component. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord, 2008