Low insulin-like growth factor I and leukopenia in anorexia nervosa
Article first published online: 22 JAN 2008
Copyright © 2008 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 41, Issue 4, pages 355–359, May 2008
How to Cite
Polli, N., Scacchi, M., Giraldi, F. P., Sormani, M., Zappulli, D. and Cavagnini, F. (2008), Low insulin-like growth factor I and leukopenia in anorexia nervosa. Int. J. Eat. Disord., 41: 355–359. doi: 10.1002/eat.20506
- Issue published online: 1 APR 2008
- Article first published online: 22 JAN 2008
- Manuscript Accepted: 16 OCT 2007
- anorexia nervosa
Considering that leukopenia and anemia are commonly observed in anorexia nervosa (AN) and that growth hormone (GH) and insulin-like growth factor-I (IGF-I) markedly influence the activation, growth and survival of hemopoietic cells, we sought for possible relationships between hematologic parameters and the GH-IGF-I axis in a group of patients with AN.
Twenty patients were studied. Leukocyte and erythrocyte counts, as well as baseline serum GH levels and IGF-I standard deviation score (SDS) values, were determined in each participant and correlations between parameters were searched.
Leukocyte and erythrocyte counts, as well as IGF-I SDS values, were significantly lower, conversely GH was significantly higher in AN patients than in normal weight participants. In patients, IGF-I SDS values were positively correlated with leukocyte count and BMI, whereas no correlation was found between IGF-I SDS and hemoglobin or erythrocytes.
The demonstration of a positive correlation between leukocyte number and circulating IGF-I in AN suggests a likely pathogenetic role of IGF-I deficiency in this hematologic abnormality. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2008