An integrative quantitative model of factors influencing the course of anorexia nervosa over time

Authors

  • Michal Yackobovitch-Gavan PhD,

    1. School of Nutritional Sciences, Faculty of Agricultural, Food, and Environmental Quality Sciences, Rehovot
    2. The Hebrew University, Jerusalem, Israel
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  • Moria Golan PhD,

    1. School of Nutritional Sciences, Faculty of Agricultural, Food, and Environmental Quality Sciences, Rehovot
    2. The Hebrew University, Jerusalem, Israel
    3. Shahaf Community Based Facility for the Treatment of Eating Disorders, Naan & Tel Aviv, Israel
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  • Avi Valevski MD,

    1. Geha Mental Health Center, Rabin Medical Center, Petah Tiqva, Israel
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    • Affiliated with the Department of Psychiatry, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

  • Shulamit Kreitler PhD,

    1. Department of Psychology, Tel Aviv University, Tel Aviv, Israel
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  • Eytan Bachar PhD,

    1. Department of Psychology, The Hebrew University, Jerusalem, Israel
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  • Amia Lieblich PhD,

    1. Department of Psychology, The Hebrew University, Jerusalem, Israel
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  • Edith Mitrani MD,

    1. Felsenstein Medical Research Center, Rabin Medical Center, Petah Tiqva, Israel
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    • Affiliated with the Department of Psychiatry, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

  • Abraham Weizman MD,

    1. Shahaf Community Based Facility for the Treatment of Eating Disorders, Naan & Tel Aviv, Israel
    2. Pediatric Psychosomatic Department, Safra Children's Hospital, The Chaim Sheba Medical Center, Tel Hashomer, Israel
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    • Affiliated with the Department of Psychiatry, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

  • Daniel Stein MD

    Corresponding author
    1. Pediatric Psychosomatic Department, Safra Children's Hospital, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Pediatric Psychosomatic Department, The Edmond and Lily Safra Children's Hospital, The Chaim Sheba Medical Center, Tel Hashomer, 52621, Israel
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    • Affiliated with the Department of Psychiatry, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel


Abstract

Objective:

To identify factors influencing the course of anorexia nervosa (AN) over time.

Method:

Former female patients with AN (36 remitted and 24 nonremitted) and 31 healthy females responded to standardized interviews and self-rating questionnaires. Remitted patients maintained normal eating, normal weight, and regular menses for the past 12 months. Patients not fulfilling these criteria were considered nonremitted.

Results:

Using logistic regression, we identified that number of hospitalizations, duration of ambulatory treatment, past vegetarianism, past anxiety, and childhood sexual abuse differentiated remitted from nonremitted patients, predicting nonremission. A similar analysis identified that elevated follow-up vegetarianism and eating-related concerns and lower body mass index (BMI) differentiated remitted from nonremitted patients, contributing to nonremission. Univariate analyses identified that remitted patients had elevated anxiety and eating-related obsessionality compared with the controls, suggesting these variables to potentially predispose to AN.

Discussion:

Elevated anxiety and eating-related obsessionality may increase the risk for the development of AN and for nonremission. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009

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