Binge-like eating in mice
Article first published online: 7 JAN 2009
Copyright © 2008 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 42, Issue 5, pages 402–408, July 2009
How to Cite
Consoli, D., Contarino, A., Tabarin, A. and Drago, F. (2009), Binge-like eating in mice. Int. J. Eat. Disord., 42: 402–408. doi: 10.1002/eat.20637
- Issue published online: 9 JUN 2009
- Article first published online: 7 JAN 2009
- Manuscript Accepted: 13 OCT 2008
- eating disorders;
- high palatable food
Given the lack of reliable murine model of binge-like eating, we tried to induce this pathological behavior in mice.
We used an experimental protocol mimicking the etiological factors involved in the development of binge eating in humans, that is, food restriction, refeeding (R-R) in presence of high palatable food, and stress (S).
Mice subjected to at least three cycles of R-R plus S (forced swimming stress), showed a binge-like behavior evident as early as 4 h, persisting 24 h after stress application and not associated to depressive-like behavior. However, after the third R-R/S cycle, food intakes of mice returned to normal levels.
(i) at least three cycles of R-R plus S are required to promote abnormal eating in mice, (ii) this is not associated to depressive-like behaviors, and (iii) the enhanced pathological behavior showed a transient nature not persisting after the third R-R/S cycle. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord, 2009