Altered striatal response to reward in bulimia nervosa after recovery
Article first published online: 11 MAY 2009
Copyright © 2009 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 43, Issue 4, pages 289–294, May 2010
How to Cite
Wagner, A., Aizenstein, H., Venkatraman, V. K., Bischoff-Grethe, A., Fudge, J., May, J. C., Frank, G. K., Bailer, U. F., Fischer, L., Putnam, K. and Kaye, W. H. (2010), Altered striatal response to reward in bulimia nervosa after recovery. Int. J. Eat. Disord., 43: 289–294. doi: 10.1002/eat.20699
- Issue published online: 1 APR 2010
- Article first published online: 11 MAY 2009
- Manuscript Accepted: 22 MAR 2009
- National Institute of Mental Health (NIMH). Grant Numbers: MH46001, MH42984, K05-MD01894
- NIMH Training Grant. Grant Number: T32-MH18399
- Price Foundation
- bulimia nervosa;
- magnetic resonance imaging;
It is possible that disturbances of systems modulating reward may contribute to a vulnerability to develop an eating disorder.
This hypothesis was tested by assessing functional magnetic resonance brain imaging response to a monetary reward task known to activate the anterior ventral striatum (AVS), a region implicated in motivational aspects toward stimuli. To avoid the confounding effects of malnutrition, 10 women who had recovered from bulimia nervosa (BN) were compared with 10 healthy comparison women (CW).
For the AVS, CW distinguished positive and negative feedback, whereas recovered BN women had similar responses to both conditions. In addition, these groups had similar patterns of findings for the dorsal caudate.
We have previously shown that individuals recovered from anorexia nervosa (AN) also had altered striatal responses and difficulties in differentiating positive and negative feedback. Thus BN and AN individuals may share a difficulty in discriminating the emotional significance of a stimulus. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010