Time course of bone loss in patients with anorexia nervosa

Authors

  • José M. Olmos MD, PhD,

    Corresponding author
    1. Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain
    • Departamento de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Avd Valdecilla s/n, 39008-Santander, Spain
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  • Carmen Valero MD, PhD,

    1. Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain
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  • Andrés Gómez del Barrio MD, PhD,

    1. Division of Psychiatry, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain
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  • José A. Amado MD, PhD, Prof,

    1. Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain
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  • José L. Hernández MD, PhD,

    1. Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain
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  • José Menéndez-Arango MD, PhD,

    1. Division of Psychiatry, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain
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  • Jesús González-Macías MD, PhD, Prof

    1. Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain
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Abstract

Objective

To evaluate the time course of bone mineral density (BMD) in women with anorexia nervosa (AN) during 2-year follow-up.

Method

We prospectively studied 51 female with AN aged 18–38 years, and 40 age-matched healthy women (19–34 years). BMD was measured in lumbar spine (LS), femoral neck (FN), and total hip (TH) by DXA.

Results

At baseline, weight, body mass index, and lumbar and hip BMD were significantly (p < .001) lower in AN patients than in controls. Patients who gain weight showed a significant increase in BMD at FN (+1.6%; p < .05), and TH (+4.4%; p < .05) and lower nonsignificant changes in LS (+1.3%). Weight at entry, and percent change of weight were significant determinants (p < .05) of the variability in percent change of BMD at FN and TH, whereas weight at entry was the main determinant of bone modifications at lumbar spine.

Discussion

Our data emphasize the influence of weight gain in recovery of bone mass in AN patients, especially at the hip. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010; 43:537–542

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