Thrombopoietin and thrombocytopenia in anorexia nervosa with severe liver dysfunction
Version of Record online: 6 OCT 2009
Copyright © 2009 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 43, Issue 7, pages 675–677, 1 November 2010
How to Cite
Yoshiuchi, K., Takimoto, Y., Moriya, J., Inada, S. and Akabayashi, A. (2010), Thrombopoietin and thrombocytopenia in anorexia nervosa with severe liver dysfunction. Int. J. Eat. Disord., 43: 675–677. doi: 10.1002/eat.20762
- Issue online: 6 OCT 2009
- Version of Record online: 6 OCT 2009
- Manuscript Accepted: 25 AUG 2009
- throm bopoitein;
- liver dysfunction;
- anorexia nervosa
Patients with anorexia nervosa (AN) display various physical complications. One such problem is thrombocytopenia. However, no studies have investigated links between AN and thrombopoietin (TPO), which is the primary regulator of megakaryocyte and platelet production produced mainly in the liver, although TPO has been recently reported to play a role in thrombocytopenia in liver diseases. We therefore clarified temporal relationships between platelet counts and TPO level in a woman with AN and severe liver dysfunction in whom platelet count decreased to 53 × 109/L.
While international normalized ratio (INR) was low, serum TPO level was relatively low despite low platelet counts. After INR and liver enzymes improved in conjunction with improved nutritional status, a rapid increase in TPO was observed and platelet count began to rise.
These findings thus suggest that decreased TPO production accompanying liver dysfunction may be related to thrombocytopenia besides myelosuppression in AN with malnutrition. © 2009 by Wiley Periodicals, Inc. (Int J Eat Disord 2010;)