Eeg in adolescent anorexia nervosa: Impact of refeeding and weight gain

Authors

  • Ainslie Hatch BA (Hons),

    Corresponding author
    1. The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
    2. School of Psychology, University of Sydney, Camperdown, Sydney, New South Wales, 2006, Australia
    • Ainslie Hatch, The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
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  • Sloane Madden MBBS, FRANZCP,

    1. Psychological Medicine, Children's Hospital at Westmead, Westmead, Sydney, New South Wales, 2145, Australia
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  • Michael R. Kohn MBBS, FRACP,

    1. The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
    2. Centre for Research into AdolescentS' Health (CRASH), Adolescent Medicine, Children's Hospital at Westmead & Westmead Hospital, Sydney, New South Wales, 2145, Australia
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  • Simon Clarke MBBS, FRACP,

    1. The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
    2. Centre for Research into AdolescentS' Health (CRASH), Adolescent Medicine, Children's Hospital at Westmead & Westmead Hospital, Sydney, New South Wales, 2145, Australia
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  • Stephen Touyz PhD,

    1. School of Psychology, University of Sydney, Camperdown, Sydney, New South Wales, 2006, Australia
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  • Evian Gordon PhD,

    1. The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
    2. Psychological Medicine, University of Sydney, Westmead Hospital, Sydney, New South Wales, 2145, Australia
    3. Brain Resource International Database, Brain Resource Company, Ultimo, New South Wales, 2007, Australia
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  • Leanne M. Williams PhD

    1. The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
    2. School of Psychology, University of Sydney, Camperdown, Sydney, New South Wales, 2006, Australia
    3. Psychological Medicine, University of Sydney, Westmead Hospital, Sydney, New South Wales, 2145, Australia
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Abstract

Objective:

To examine resting awake EEG in adolescent AN participants before and after refeeding to determine if EEG abnormalities in Anorexia Nervosa (AN) are reversible.

Method:

In 37 adolescent first admission AN patients and 45 healthy controls, EEG was recorded during short duration “eyes open” and “eyes closed” awake resting conditions. Repeat testing occurred in 28 AN participants after refeeding and subsequent weight gain.

Results:

In “eyes open,” underweight AN participants exhibit reduced relative alpha power and increased beta power in frontal brain regions. A significant increase in alpha, and decrease in beta and delta power was observed within participants after refeeding. In “eyes closed”, underweight AN participants had elevated theta in parietal-occipital regions which remained after refeeding.

Discussion:

EEG abnormalities (reduced alpha/increased beta power) in AN normalizes with refeeding, while increased theta power persists in parietal-occipital regions in an eyes closed context. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:65–75)

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