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Keywords:

  • binge eating disorder;
  • pharmacotherapy;
  • sodium oxybate

Abstract

Objective:

To assess preliminarily the effectiveness of sodium oxybate in binge eating disorder.

Method:

This was an open-label, prospective, 16-week, flexible dose study of sodium oxybate in binge eating disorder. The primary outcome was binge eating episode frequency.

Results:

Twelve individuals received sodium oxybate, 10 completed at least one postbaseline evaluation, and five completed the study. Mean dose at endpoint was 7.1 (2.0) g/day. Sodium oxybate was associated with significant reductions in frequency of binge days and binge episodes, as well as measures of clinical severity, eating pathology, obsessive-compulsive symptoms, food cravings, body mass index, and body weight. Nine participants had remission of binge eating and five lost ≥5% of their baseline weight; all five of the latter participants had remission of binge eating.

Discussion:

In this open-label trial, sodium oxybate was effective in binge eating disorder, but associated with high a discontinuation rate. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:262–268)