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Keywords:

  • anorexia nervosa;
  • bulimia nervosa;
  • atypical antipsychotics;
  • aripipra-zole;
  • long-term follow up;
  • dopamine

Abstract

Objective:

There has been much interest in the use of atypical antipsychotics in anorexia nervosa (AN). However, newer, more weight-neutral medications have not been studied in AN, and there are no reports of the use of antipsychotics in bulimia nervosa (BN).

Method:

We report on the treatment of eight patients (five with AN and three with BN) with aripiprazole for time periods of four months to more than three years.

Results:

All individuals had reduced distress around eating, fewer obsessional thoughts about food, weight and body image, significant lessening of eating-disordered behaviors, and gradual weight restoration where appropriate. Depression, generalized anxiety, and cognitive flexibility improved as well.

Discussion:

In summary, these findings support the need to perform controlled trials of aripiprazole in AN and BN. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:269–275)