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Keywords:

  • renal function;
  • estimation;
  • eating disorders;
  • renal failure;
  • anorexia nervosa;
  • bulimia nervosa

Abstract

Background:

Renal function could be evaluated with different equations such as Cockcroft–Gault formula (C-G), Mayo Clinic Quadratic (MAYO) and four MDRD variables. Clinical application of different formulae in conditions with severe energy restriction or in obese subjects is still a matter of investigation.

Method:

Renal function of 55 anorexia nervosa (AN) and 44 bulimia nervosa (BN) patients was evaluated with C-G formula for creatinine clearance calculation, and glomerular filtration rate (GFR) was estimated with MAYO and MDRD equations.

Results:

BN group was older and had higher weight, body mass index (BMI), body surface area than AN subjects; however, their mean BMI was in the normal range. AN group had better renal function than BN one when it was evaluated with MAYO and MDRD; on the contrary, it was worse when it was calculated with C-G. The results obtained from the three formulae were poorly correlated and Bland–Altman analysis confirmed that the results of the three formulae were not in agreement.

Discussion:

C-G is inaccurate when it is applied to obese or cachectic subjects. MDRD underestimates renal function in normal-high GFR. MAYO seems to be a good alternative to the other equations leading to correct classification of patients; therefore, it should be used to diagnose eating disorder subjects as renal insufficient. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:233–237)