Supported by INCITE08PXIB211069PR from Xunta de Galicia and by PSI2008-01081/PSIC from Ministerio de Educación y Ciencia de España, and by the Venres Clinicos Unit of the University of Santiago de Compostela.
Correlates & Mediators of Psychopathology
Heat makes a difference in activity-based anorexia: A translational approach to treatment development in anorexia nervosa†
Article first published online: 15 NOV 2010
Copyright © 2010 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 45, Issue 1, pages 26–35, January 2012
How to Cite
Cerrato, M., Carrera, O., Vazquez, R., Echevarría, E. and Gutierrez, E. (2012), Heat makes a difference in activity-based anorexia: A translational approach to treatment development in anorexia nervosa. Int. J. Eat. Disord., 45: 26–35. doi: 10.1002/eat.20884
- Issue published online: 14 DEC 2011
- Article first published online: 15 NOV 2010
- Manuscript Accepted: 11 SEP 2010
- semistarvation induced hyperactivity;
- activity anorexia;
- activity-induced anorexia;
- heat treatment;
- weight restoration;
- translational research
To test the effect of raising ambient temperature (AT) on activity-based anorexia (ABA) and to extend to female rats previous findings reported in male animals.
Two studies are reported in which female rats were submitted to food restriction and free access to an activity wheel either separately or in combination under changing (21–32°C) or constant AT (21°C).
Warming ABA animals reversed running activity, preserved food-intake, and enabled female rats to recover from acute weight loss. Moreover, sedentary food-restricted warmed rats maintained a body weight equivalent to the levels of animals housed at standard AT in spite of 20% reduced food-intake.
The replication on female rats corroborates the effect previously reported for males, which is indicative of the robust effect of AT in recovering rats from ABA. The findings reported here represent strong preclinical evidence in favor of heat supply as a useful adjunctive component for the treatment of anorexia nervosa (AN). © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)