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Keywords:

  • anorexia;
  • weight restoration;
  • twins;
  • olanzapine;
  • fluoxetine

Abstract

Objective:

No studies have compared the response to selective serotonin reuptake inhibitors and atypical antipsychotics in anorexia nervosa. This case study examines such a comparison.

Method:

This report describes a case of 12-year-old identical twins with anorexia nervosa, one of whom was treated with olanzapine and the other with fluoxetine, while undergoing family therapy.

Results:

Twin A treated with fluoxetine went from 75 to 84.4% ideal body weight, while Twin B treated with olanzapine went from 72 to 99.9% ideal body weight over the course of 9 months.

Discussion:

This case supports the need for adequately powered, controlled clinical trials to test the efficacy of olanzapine in adolescents presenting with anorexia nervosa. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)