Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa
Article first published online: 22 FEB 2011
Copyright © 2011 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 45, Issue 2, pages 294–297, March 2012
How to Cite
Duvvuri, V., Cromley, T., Klabunde, M., Boutelle, K. and Kaye, W. H. (2012), Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa. Int. J. Eat. Disord., 45: 294–297. doi: 10.1002/eat.20917
- Issue published online: 7 FEB 2012
- Article first published online: 22 FEB 2011
- Manuscript Accepted: 9 DEC 2010
- Davis Foundation Fellowship in Eating Disorders, University of Pittsburgh and the University of California, San Diego. Grant Numbers: MH074508, 5T32MH018399
- NIH/NIMH,Astra-Zeneca, Lundbeck and Merck
- weight restoration;
No studies have compared the response to selective serotonin reuptake inhibitors and atypical antipsychotics in anorexia nervosa. This case study examines such a comparison.
This report describes a case of 12-year-old identical twins with anorexia nervosa, one of whom was treated with olanzapine and the other with fluoxetine, while undergoing family therapy.
Twin A treated with fluoxetine went from 75 to 84.4% ideal body weight, while Twin B treated with olanzapine went from 72 to 99.9% ideal body weight over the course of 9 months.
This case supports the need for adequately powered, controlled clinical trials to test the efficacy of olanzapine in adolescents presenting with anorexia nervosa. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)