Dr. Kaye has received salary support from the University of Pittsburgh and the University of California, San Diego; Research funding/support from the NIMH; Research funding for an investigator initiated treatment study from Astra-Zeneca and consulting fees from Lundbeck and Merck and the Eating Disorder Center of Denver. In addition, there are honoraria for presentations from academic institutions and meetings, and compensation for grant review activities from the National Institutes of Health. Dr. Bailer has received salary support from the Hilda & Preston Davis Foundation and the Price Foundation. Dr. Mathis has received royalty payments for licensed technology from GE Healthcare and Neuroptix as well as research grant support from Neuroptix. Dr. Mathis also served as a consultant for Janssen/Elan, Wyeth/Pfizer, and Novartis over the past three years. Dr. Frankle has received salary support from the University of Pittsburgh, research funding/support from the NIMH and NIDA as well as research funding and consulting fees from Sepracor, Inc. Dr. Duvvuri has received salary support from a Hilda & Preston Davis Foundation Fellowship in Eating Disorders Research and from a NIMH T32 fellowship. The remaining authors, Dr. Narendran and M. Himes declare that, except for income received from their primary employers and the aforementioned funding, no further financial support or compensation has been received from any individual or corporate entity over the past 3 years for research or professional service and there are no personal financial holdings that could be perceived as constituting a potential conflict of interest.
Article first published online: 3 MAY 2011
Copyright © 2011 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 45, Issue 2, pages 263–271, March 2012
How to Cite
Bailer, U. F., Narendran, R., Frankle, W. G., Himes, M. L., Duvvuri, V., Mathis, C. A. and Kaye, W. H. (2012), Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa. Int. J. Eat. Disord., 45: 263–271. doi: 10.1002/eat.20937
Supported by MH046001, MH042984, K05-MH001894 from the National Institute of Mental Health and by the Prince Foundation.
- Issue published online: 7 FEB 2012
- Article first published online: 3 MAY 2011
- Manuscript Accepted: 13 MAR 2011
- anorexia nervosa;
- positron emission tomography
Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function.
We used an amphetamine challenge and positron emission tomography [11C]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared with 9 control women (CW).
REC AN and CW were similar for baseline, postamphetamine [11C]raclopride binding potential (BPND) and change (Δ) in BPND for all regions. In CW, ventral striatum Δ BPND was associated with euphoria (r = −0.76; p = 0.03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Δ BPND in the precommissural dorsal caudate (r = −0.62, p = 0.05).
REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food-related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)