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Keywords:

  • duloxetine;
  • binge eating disorder;
  • depression;
  • obesity;
  • longitudinal analysis

Abstract

Objective:

This study evaluated duloxetine in the treatment of binge eating disorder (BED) with comorbid current depressive disorders.

Method:

In this 12-week, double-blind, placebo-controlled trial, 40 patients with Diagnostic and Statistical Manual of Mental Disorders-IV-TR BED and a comorbid current depressive disorder received duloxetine (N = 20) or placebo (N = 20). The primary outcome measure was weekly binge eating day frequency.

Results:

In the primary analysis, duloxetine (mean 78.7 mg/day) was superior to placebo in reducing weekly frequency of binge eating days (p = .04), binge eating episodes (p = .02), weight (p = .04), and Clinical Global Impression-Severity of Illness ratings for binge eating (p = .02) and depressive disorders (p = .01). Changes in body mass index and measures of eating pathology, depression, and anxiety did not differ between the two groups.

Discussion:

Duloxetine may be effective for reducing binge eating, weight, and global severity of illness in BED with a comorbid current depressive disorder, but this finding needs confirmation in larger, placebo-controlled trials. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)