Respiratory functions in adolescents hospitalized for anorexia nervosa: A prospective study
Article first published online: 7 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 45, Issue 3, pages 415–422, April 2012
How to Cite
Kerem, N. C., Averin, E., Riskin, A., Tov, N., Srugo, I. and Kugelman, A. (2012), Respiratory functions in adolescents hospitalized for anorexia nervosa: A prospective study. Int. J. Eat. Disord., 45: 415–422. doi: 10.1002/eat.20960
- Issue published online: 8 MAR 2012
- Article first published online: 7 SEP 2011
- Manuscript Accepted: 21 JUL 2011
- anorexia nervosa;
- carbon dioxide;
- pulmonary function tests;
To examine the effects of malnourishment on the respiratory system of adolescents with anorexia nervosa (AN) hospitalized for medical stabilization.
Prospective study. Study group: hospitalized adolescents with recent onset (<1 year) AN. Control group: adolescents hospitalized for other diagnoses. Excluded: participants with lung disease.
Patients' characteristics (mean ± SD) for the AN (n = 16) and the control group (n = 13) on admission were: age: 15.0 ± 1.7 vs. 15.2 ± 1.4 years, p = 0.7; body mass index (BMI): 15.5 ± 2.3 vs. 19.8 ± 2.9 kg/m2, p < 0.001; venous pH 7.34 ± 0.02 vs. 7.38 ± 0.03, p < 0.001; PCO2 53.3 ± 4.1 vs. 42.5 ± 3.1 mm Hg, p < 0.001; and HCO3 28.7 ± 2.0 vs. 25.3 ± 2.4 meq/L, p < 0.001, respectively. Therewere no significant differences in nocturnal respiratory rates, pulse-oximetry oxygen saturations, or end-tidal CO2. Pulmonary function tests (PFTs) in adolescents with AN revealed no obstructive, restrictive, or significant pulmonary vascular disease except for lower peak expiratory flow rates (PEFRs). During hospitalization (12.3 ± 3.8 days), their weight, BMI, mean nocturnal heart rate, and respiratory rate increased significantly, while their venous PCO2 and HCO3 decreased significantly without significant changes in PFTs.
Adolescents with recent onset AN, admitted for medical stabilization, demonstrate hypercapnia despite normal PFTs, except for decreased PEFRs. These could result from decreased respiratory muscle strength and/or abnormal control of breathing. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)