Supported by R15MH077654-01A1 from NIMH and by P20 RR016479 from NCRR.
Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women†
Version of Record online: 23 JAN 2012
Copyright © 2012 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 45, Issue 4, pages 492–500, May 2012
How to Cite
Stoltenberg, S. F., Anderson, C., Nag, P. and Anagnopoulos, C. (2012), Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women. Int. J. Eat. Disord., 45: 492–500. doi: 10.1002/eat.20976
- Issue online: 6 APR 2012
- Version of Record online: 23 JAN 2012
- Manuscript Accepted: 16 OCT 2011
- NIMH. Grant Number: R15MH077654-01A1
- NCRR. Grant Number: P20 RR016479
- early life stress;
- genotype by environment interaction
This study investigated a potential interaction between the triallelic polymorphism of the serotonin transporter gene (SLC6A4) promoter and the experience of childhood trauma on the number of problem eating behaviors.
The study sample was comprised of 439 (64.7% female) Caucasian college students (mean age = 22.49, SD = 6.12). Participants completed questionnaires that assessed eating problems and experience of trauma in childhood (ages 0–12) and donated cheek cells for 5-HTTLPR and rs25531 genotyping.
Women carrying a lower expressing allele (i.e., LG or S) who were exposed to higher levels of childhood trauma reported significantly higher mean numbers of eating problems (gender × genotype × trauma interaction, p = .006).
These results are consistent with findings that the lower expressing alleles of the SLC6A4 promoter are associated with increased sensitivity to the negative impact of childhood stressors on adult behavioral outcomes. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)